Ro 20-0657/000
Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine.
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- CAS No.: 29606-06-2
- 화학식: C14H18N4O4
- 분자량:306.32
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Chemical Information
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CAS No. 29606-06-2
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Appearance Solid
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분자량 306.32
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화학식 C14H18N4O4
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Color White to off-white
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SMILES
OC(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N)N=C2N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
[2]. van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579(2):354-60. [Content Brief]
[3]. Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411(20):5209-5222. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 20-0657/000 Related Classifications
HY-100622 Related Classifications
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