29606-06-2
29606-06-2
Chemical Structure
Ro 20-0657/000
- CAS No.: 29606-06-2
- Formula:C14H18N4O4
- Molecular Weight:306.32
IUPAC Name: (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanol
InChIKey: ZQRSRBQVQNNQKD-UHFFFAOYSA-N
SMILES: OC(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N)N=C2N
Biological Activity: Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine[1][2][3].
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Ro 20-0657/000 | Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine. | |||||||||||||||||||||
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Ro 20-0657/000-d3 | Ro 20-0657/000-d3 is the deuterium labeled Ro 20-0657/000 (HY-100622). Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine. | |||||||||||||||||||||
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References
- [1]. Robert E. London, et al. Nuclear magnetic resonance study of interaction of ligands with Streptococcus faecium dihydrofolate reductase labeled with [.gamma.-13C]tryptophan. Biochemistry 1982, 21, 18, 4450-4458.
- [2]. van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579(2):354-60. [Content Brief]
- [3]. Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411(20):5209-5222. [Content Brief]
