2. Others Metabolic Enzyme/Protease
  3. Biochemical Assay Reagents Drug Metabolite
  4. 1,7-Dimethyluric acid

1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H2O2, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions.

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1,7-Dimethyluric acid

1,7-Dimethyluric acid Chemical Structure

CAS No. : 33868-03-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of 1,7-Dimethyluric acid:

1,7-Dimethyluric acid Related Antibodies

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Description

1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H2O2, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

1,7-Dimethyluric acid undergoes electrochemical oxidation, yielding N-methylurea and 1-methylalloxan at pH 3.0, and 1-methyl-5-hydroxyhydantoin-5-(N-methylcarboxamide) at pH 7.0, across PGE, GCE, and Pt electrodes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,7-Dimethyluric acid Related Antibodies
Molecular Weight

196.16

Formula

C7H8N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C)NC2=C(N(C)C(N2)=O)C1=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (50.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0979 mL 25.4894 mL 50.9788 mL
5 mM 1.0196 mL 5.0979 mL 10.1958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0979 mL 25.4894 mL 50.9788 mL 127.4470 mL
5 mM 1.0196 mL 5.0979 mL 10.1958 mL 25.4894 mL
10 mM 0.5098 mL 2.5489 mL 5.0979 mL 12.7447 mL
15 mM 0.3399 mL 1.6993 mL 3.3986 mL 8.4965 mL
20 mM 0.2549 mL 1.2745 mL 2.5489 mL 6.3723 mL
25 mM 0.2039 mL 1.0196 mL 2.0392 mL 5.0979 mL
30 mM 0.1699 mL 0.8496 mL 1.6993 mL 4.2482 mL
40 mM 0.1274 mL 0.6372 mL 1.2745 mL 3.1862 mL
50 mM 0.1020 mL 0.5098 mL 1.0196 mL 2.5489 mL
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1,7-Dimethyluric acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,7-Dimethyluric acid33868-03-0Biochemical Assay ReagentsDrug Metaboliteplatinum electrodesuric acidpyrolytic graphite electrodes1-methylalloxanpyrimidine ringN-methylureaglassy carbon electrodesdiimine intermediatepurine derivativeperoxidaseInhibitorinhibitorinhibit

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