Monoethylglycinexylidide hydrochloride
Based on 1 Customer Validation
Monoethylglycinexylidide hydrochloride (MEGX hydrochloride; Norlidocaine hydrochloride) is the major metabolite of Lidocaine (HY-B0185), produced via oxidative metabolism by cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide hydrochloride can be used for research on liver cirrhosis.
For research use only. We do not sell to patients.
- Purity: 98.82%
- CAS No.: 7729-94-4
- Formula: C12H19ClN2O
- Molecular Weight:242.75
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-114914
3-Hydroxylidocaine -
HY-W099331R
Monoethylglycinexylidide hydrochloride (Standard) -
HY-B0602
Desvenlafaxine -
HY-137397
8-Hydroxyefavirenz -
HY-W011235
Norfluoxetine hydrochloride -
HY-145531
Mirtazapine N-oxide -
HY-126857
5-Hydroxyomeprazole -
HY-W016033
Pantoprazole sulfide -
HY-W008614
Lansoprazole sulfone -
HY-B0602R
Desvenlafaxine (Standard) -
HY-122139
Desethylene Ciprofloxacin hydrochloride
Biological Activity
Description
In Vivo
Monoethylglycinexylidide hydrochloride shows significantly higher peak plasma concentration induced by 2.5% lidocaine/2.5% prilocaine eutectic mixture than single 4% lidocaine cream and 6% lidocaine compound preparation. Impaired liver metabolic function leads to increased residual levels of Monoethylglycinexylidide hydrochloride in plasma[1].
Monoethylglycinexylidide (MEGX) (formed within 0-90 min after intravenous administration of 1 mg/kg Lidocaine) hydrochloride shows no statistically significant difference in plasma concentrations between healthy control samples and samples from patients with mild, moderate, or severe chronic viral liver injury. Multiple extrahepatic interfering factors disrupt its formation process and reduce detection accuracy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 7729-94-4
-
Appearance Solid
-
Molecular Weight 242.75
-
Formula C12H19ClN2O
-
Color White to off-white
-
SMILES
CCNCC(NC1=C(C)C=CC=C1C)=O.Cl
-
Synonyms
MEGX hydrochloride; Norlidocaine hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 5 mg/mL (20.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Oni G, et al. Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX). Aesthetic surgery journal. 2012 May;32(4):495-503. [Content Brief]
[2]. Elin RJ, et al. Assessment of monoethylglycinexylidide as measure of liver function for patients with chronic viral hepatitis. Clinical chemistry. 1997 Oct;43(10):1952-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1195 mL | 20.5973 mL | 41.1946 mL | 102.9866 mL |
| 5 mM | 0.8239 mL | 4.1195 mL | 8.2389 mL | 20.5973 mL | |
| 10 mM | 0.4119 mL | 2.0597 mL | 4.1195 mL | 10.2987 mL | |
| 15 mM | 0.2746 mL | 1.3732 mL | 2.7463 mL | 6.8658 mL | |
| 20 mM | 0.2060 mL | 1.0299 mL | 2.0597 mL | 5.1493 mL |
Monoethylglycinexylidide hydrochloride Related Classifications
HY-W099331 Related Classifications
Powered by Bioz