2. Disease Areas
  3. Digestive System Disease
  4. Liver Disease
  5. Hepatic Cirrhosis

Hepatic Cirrhosis

Hepatic cirrhosis, or liver cirrhosis, is a chronic liver disease characterized by the replacement of healthy liver tissue with fibrous scar tissue, leading to impaired liver function. It is associated with conditions such as alcoholic liver cirrhosis and primary biliary cholangitis, and presents with symptoms including abdominal pain, constipation, and diarrhea. The FARSB gene has been implicated in the pathogenesis of this disorder, with related biological pathways involving regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs), as well as processes in embryonic and induced pluripotent stem cells. Treatment considerations include drugs such as Vancomycin and Imipenem, and affected tissues include the liver, blood, and bone.

Hepatic Cirrhosis (5):

Art. -Nr. Produktname CAS. Nr. Reinheit Chemische Struktur
  • HY-183637
    E822-1968 1037259-63-4
    E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
    E822-1968
  • HY-185277
    6β-Hydroxy-7α-thiomethylspirolactone 42219-60-3
    6β-Hydroxy-7α-thiomethylspirolactone is a metabolite of Spironolactone (HY-B0561). 6β-Hydroxy-7α-thiomethylspirolactone can be used in studies of cirrhotic ascites.
    6β-Hydroxy-7α-thiomethylspirolactone
  • HY-183636
    M353-0039 1185074-29-6
    M353-0039 is a selective UT-A2 inhibitor with a human IC50 of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
    M353-0039
  • HY-D3191
    L&M-D-MR
    L&M-D-MR is a highly specific fluorescent "AND" logic probe with response moieties for leucine aminopeptidase (LAP) and monoamine oxidase (MAO). The coexistence of both LAP and MAO is required for L&M-D-MR to trigger intramolecular cyclization, release fluorophores and activate fluorescence. In the presence of only a single enzyme, L&M-D-MR generates only an extremely weak signal. L&M-D-MR enables bioimaging in living cells and mouse models, and can effectively distinguish different subtypes of liver diseases via blood samples or test strips. L&M-D-MR is widely used in studies related to liver cirrhosis, hepatitis B and drug-induced liver injury.
    L&M-D-MR
  • HY-181139
    ALK5-IN-86
    ALK5-IN-86 (Compound 22f) is a selective ALK5 inhibitor with an IC50 of 0.267 μM. ALK5-IN-86 forms hydrogen bonds with key amino acid residues in the active site of ALK5. ALK5-IN-86 is applicable to the research of diseases such as liver fibrosis.
    ALK5-IN-86