2. Membrane Transporter/Ion Channel
  3. Urea Transporter
  4. E822-1968

E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

For research use only. We do not sell to patients.

E822-1968

E822-1968 Chemical Structure

CAS No. : 1037259-63-4

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E822-1968 Related Antibodies

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Description

E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis[1].

In Vitro

E822-1968 potently inhibits UT-A2-mediated urea transport in UT-A2-overexpressing HEK293F cells with an IC50 of 0.44 μM[1].
E822-1968 weakly inhibits UT-A3-mediated urea transport in UT-A3-overexpressing HEK293F cells with an IC50 of 3.42 μM[1].
E822-1968 (10 nM-100 μM; 50 seconds) does not inhibit UT-B-mediated urea transport in UT-B-overexpressing HEK293F cells[1].
E822-1968 (1-10 μM; 30 minutes) does not inhibit rat UT-A1-mediated urea transport in stably expressing MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E822-1968 Related Antibodies
Molecular Weight

337.37

Formula

C19H19N3O3
CAS No.
SMILES

COC1=CC(CNC(C2=CC(C3=CC=CC(OC)=C3)=NN2)=O)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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E822-1968 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E822-19681037259-63-4Urea TransporterMDCK cellsrenal medullarat UT-A1UT-A2UT-BUT-A3HEK293F cellsATC subpocketmiceInhibitorinhibitorinhibit

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