Hyponatremia
Hyponatremia is the most common electrolyte disorder in hospitalized patients, defined as a serum sodium concentration below 135 mmol/L (or less than 136 mmol/L in some definitions), resulting from sodium depletion due to causes such as diarrhea, excessive sweating, or adrenal insufficiency. It is characterized by low plasma sodium levels and frequently leads to central nervous system dysfunction, manifesting clinically as nausea, cognitive impairment, depression, convulsions, and in severe cases, coma. The severity and rapidity of sodium decline significantly influence the neurological symptoms observed.
References:
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Hyponatremia (2)
M353-0039
Cat. No.: HY-183636
CAS No.: 1185074-29-6
- Formula: C16H15N3O3S2
- Molecular Weight: 361.44
M353-0039 is a selective UT-A2 inhibitor with a human IC50 of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
E822-1968
Cat. No.: HY-183637
CAS No.: 1037259-63-4
- Formula: C19H19N3O3
- Molecular Weight: 337.37
E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
