Hyponatremia

Hyponatremia is the most common electrolyte disorder in hospitalized patients, defined as a serum sodium concentration below 135 mmol/L (or less than 136 mmol/L in some definitions), resulting from sodium depletion due to causes such as diarrhea, excessive sweating, or adrenal insufficiency. It is characterized by low plasma sodium levels and frequently leads to central nervous system dysfunction, manifesting clinically as nausea, cognitive impairment, depression, convulsions, and in severe cases, coma. The severity and rapidity of sodium decline significantly influence the neurological symptoms observed.

References:

[1]. Hyponatremia. sciencedirect.

Hyponatremia (2):

Targets:	Urea Transporter (2)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-183636

M353-0039	1185074-29-6
M353-0039 is a selective UT-A2 inhibitor with a human IC₅₀ of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

HY-183637

E822-1968	1037259-63-4
E822-1968 is an UT-A2 inhibitor with a human IC₅₀ of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

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