1. Membrane Transporter/Ion Channel
  2. Sodium Channel

Lidocaine (Synonyms: Lignocaine)

Cat. No.: HY-B0185 Purity: 99.52%
Handling Instructions

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.

For research use only. We do not sell to patients.

Lidocaine Chemical Structure

Lidocaine Chemical Structure

CAS No. : 137-58-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g USD 96 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Other Forms of Lidocaine:

Top Publications Citing Use of Products

    Lidocaine purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx. Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself. Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (426.73 mM)

    H2O : ≥ 5 mg/mL (21.34 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.2673 mL 21.3365 mL 42.6730 mL
    5 mM 0.8535 mL 4.2673 mL 8.5346 mL
    10 mM 0.4267 mL 2.1337 mL 4.2673 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

    References
    Molecular Weight

    234.34

    Formula

    C₁₄H₂₂N₂O

    CAS No.

    137-58-6

    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN(CC)CC

    Storage

    4°C, protect from light

    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Product Name:
    Lidocaine
    Cat. No.:
    HY-B0185
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    Lidocaine

    Cat. No.: HY-B0185