1. Membrane Transporter/Ion Channel
    MAPK/ERK Pathway
    Stem Cell/Wnt
    NF-κB
    Apoptosis
  2. Sodium Channel
    MEK
    ERK
    NF-κB
    Apoptosis
  3. Lidocaine hydrochloride hydrate

Lidocaine hydrochloride hydrate (Synonyms: Lignocaine hydrochloride hydrate)

Cat. No.: HY-B0185B
Handling Instructions

Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia.

For research use only. We do not sell to patients.

Lidocaine hydrochloride hydrate Chemical Structure

Lidocaine hydrochloride hydrate Chemical Structure

CAS No. : 6108-05-0

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Top Publications Citing Use of Products

    Lidocaine hydrochloride hydrate purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

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    Description

    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia[1][2].

    IC50 & Target[1][2]

    ERK

     

    NF-κB

     

    MEK

     

    In Vitro

    Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
    Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours[2].
    Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
    Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Decreased significantly cell proliferation.

    Cell Viability Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 1, 5 and 10 nM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibited MKN45 cell viability.

    Apoptosis Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Increased significantly the apoptotic cell rate.

    Western Blot Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10 nM
    Incubation Time: 48 hours
    Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
    In Vivo

    Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    288.81

    Formula

    C14H25ClN2O2

    CAS No.
    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN(CC)CC.Cl.O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Product Name:
    Lidocaine hydrochloride hydrate
    Cat. No.:
    HY-B0185B
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