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Lidocaine hydrochloride

(Synonyms: Lignocaine hydrochloride)
23 Cited Publications
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Based on 23 publication(s) in Google Scholar

Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.

For research use only. We do not sell to patients.

  • Purity: 99.84%
  • CAS No.: 73-78-9
  • Formula: C14H23ClN2O
  • Molecular Weight:270.80
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Lidocaine hydrochloride Chemical Structure
    Lidocaine hydrochloride Chemical Structure
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
  • Experimental Validation Results for Lidocaine hydrochloride
CAS No.: 73-78-9
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  • RT-PCR
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  • Cell Imaging/Staining
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  • Lidocaine hydrochloride Chemical Structure
    Lidocaine hydrochloride Chemical Structure
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    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     RT-PCR analysis of ZDHHC15 mRNA levels in GSCs treated with different concentrations (5, 10, and 20 μM) of Prilocaine, Lidocaine, Procaine, and Ropivacaine. β-Actin was used as a loading control.

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Local anesthetics Prilocaine, Lidocaine (5-20 μM, 24-48 h), Procain, and Ropivacaine impaired cell survival through inhibition of ZDHHC15 expression.

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Representative images showing U251 GSCs maintained under neurosphere conditions for 7 days after transfection with ZDHHC15 shRNA or treatment with prilocaine, lidocaine, procaine, or ropivacaine (20 μM).

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     Representative images showing U251 GSCs maintained under neurosphere conditions for 7 days after transfection with ZDHHC15 shRNA or treatment with prilocaine, lidocaine, procaine, or ropivacaine (20 μM). GSC neurospheres of all categories were stained for stem and differentiated cell markers as indicated. Cells were stained with antibodies against nestin and SOX2 for neural stem cell markers, and antibody staining of GFAP and MAP 2 were used as markers of differentiated cells. DAPI (4′,6-diamidino-2-phenylindole) was used as a nuclear stain.

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     The expression of GP130 in U251 GSCs (monolayer culture) transfected with ZDHHC5 shRNA and treated with Prilocaine, Lidocaine, Procaine, and Ropivacaine (20 μM) for 48 h was analyzed by immunofluorescence staining. Scale bar, 100 μm.

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Feb 4;12(1):107. [Abstract]

    Customer Validation
     GSCs were transfected with ZDHHC5 shRNA or treated with Prilocaine, Lidocaine, Procaine, and Ropivacaine (20 μM) and harvested after 48 h. Cellular fractionation was performed to separate cytosolic and membrane fractions.

  • 1/16

    Lidocaine hydrochloride purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211. [Abstract]

    Customer Validation
     Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

  • Lidocaine hydrochloride