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Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels

J Physiol. 2007 Jul 1;582(Pt 1):11. doi: 10.1113/jphysiol.2007.136671.

Theodore R Cummins ¹

Affiliations

PMID: 17525109 DOI: 10.1113/jphysiol.2007.136671

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-B0185

Lidocaine

99.96%, Na+ Channel Blocker

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185A

Lidocaine hydrochloride

99.84%, Na+ Channel Blocker

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185B

Lidocaine hydrochloride hydrate

99.80%, Na+ Channel Blocker

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185S1

Lidocaine-d₁₀

99.58%, Stable Isotope

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185AS

Lidocaine-d₁₀ hydrochloride

99.79%, Stable Isotope

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185G

Lidocaine (GMP)

Na+ Channel Blocker

target: MEK; NF-κB; Sodium Channel; Apoptosis; ERK

Research Areas: Cancer
HY-B0185AS1

Lidocaine-d₆ hydrochloride

Stable Isotope

target: Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185BR

Lidocaine hydrochloride hydrate (Standard)

Na+ Channel Blocker

target: Reference Standards; Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185S

N-Oxide Lidocaine-d₁₀

Stable Isotope

target: Isotope-Labeled Compounds; Sodium Channel; MEK; ERK; NF-κB; Apoptosis

Research Areas: Cardiovascular Disease; Cancer
HY-B0185S2

Lidocaine-d₆

Stable Isotope

target: MEK; NF-κB; Sodium Channel; Apoptosis; Isotope-Labeled Compounds; ERK

Research Areas: Cardiovascular Disease; Cancer