1. Metabolic Enzyme/Protease
    Others
    Autophagy
  2. Mineralocorticoid Receptor
    Androgen Receptor
    Autophagy
  3. Spironolactone

Spironolactone (Synonyms: SC9420)

Cat. No.: HY-B0561 Purity: 99.75%
Handling Instructions

Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.

For research use only. We do not sell to patients.

Spironolactone Chemical Structure

Spironolactone Chemical Structure

CAS No. : 52-01-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 158 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Spironolactone

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

Clinical Trial
Molecular Weight

416.57

Formula

C24H32O4S

CAS No.
SMILES

C[[email protected]@]12[[email protected]](OC3=O)(CC3)CC[[email protected]@]1([H])[[email protected]@]([[email protected]@H](CC4=CC5=O)SC(C)=O)([H])[[email protected]]([[email protected]]4(CC5)C)([H])CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (120.03 mM)

H2O : 0.1 mg/mL (0.24 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4006 mL 12.0028 mL 24.0056 mL
5 mM 0.4801 mL 2.4006 mL 4.8011 mL
10 mM 0.2401 mL 1.2003 mL 2.4006 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.75%

References
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Product Name:
Spironolactone
Cat. No.:
HY-B0561
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