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  2. Androgen Receptor
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  3. Spironolactone

Spironolactone (Synonyms: SC9420)

Cat. No.: HY-B0561 Purity: 96.17%
Handling Instructions

Spironolactone is a potent antagonist of the androgen receptor.

For research use only. We do not sell to patients.

Spironolactone Chemical Structure

Spironolactone Chemical Structure

CAS No. : 52-01-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 144 In-stock
Estimated Time of Arrival: December 31
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Description

Spironolactone is a potent antagonist of the androgen receptor. Target: Androgen Receptor Spironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (120.03 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4006 mL 12.0028 mL 24.0056 mL
5 mM 0.4801 mL 2.4006 mL 4.8011 mL
10 mM 0.2401 mL 1.2003 mL 2.4006 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

416.57

Formula

C₂₄H₃₂O₄S

CAS No.

52-01-7

SMILES

C[[email protected]@]12[[email protected]](OC3=O)(CC3)CC[[email protected]@]1([H])[[email protected]@]([[email protected]@H](CC4=CC5=O)SC(C)=O)([H])[[email protected]]([[email protected]]4(CC5)C)([H])CC2

Shipping

Room temperature in continental US; may vary elsewhere

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Spironolactone
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HY-B0561
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Spironolactone

Cat. No.: HY-B0561