1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  2. 5-HT Receptor Calcium Channel Drug Metabolite
  3. Norfluoxetine hydrochloride

Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity.

For research use only. We do not sell to patients.

Norfluoxetine hydrochloride Chemical Structure

Norfluoxetine hydrochloride Chemical Structure

CAS No. : 57226-68-3

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5 mg USD 160 In-stock
10 mg USD 250 In-stock
25 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Norfluoxetine hydrochloride:

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4].

IC50 & Target[1]

5-HT Receptor

 

CaV3.3

5 μM (IC50)

In Vivo

Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.76

Formula

C16H17ClF3NO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC=C(OC(C2=CC=CC=C2)CCN)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (376.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0142 mL 15.0711 mL 30.1423 mL
5 mM 0.6028 mL 3.0142 mL 6.0285 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.01%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0142 mL 15.0711 mL 30.1423 mL 75.3557 mL
5 mM 0.6028 mL 3.0142 mL 6.0285 mL 15.0711 mL
10 mM 0.3014 mL 1.5071 mL 3.0142 mL 7.5356 mL
15 mM 0.2009 mL 1.0047 mL 2.0095 mL 5.0237 mL
20 mM 0.1507 mL 0.7536 mL 1.5071 mL 3.7678 mL
25 mM 0.1206 mL 0.6028 mL 1.2057 mL 3.0142 mL
30 mM 0.1005 mL 0.5024 mL 1.0047 mL 2.5119 mL
40 mM 0.0754 mL 0.3768 mL 0.7536 mL 1.8839 mL
50 mM 0.0603 mL 0.3014 mL 0.6028 mL 1.5071 mL
60 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2559 mL
80 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9419 mL
100 mM 0.0301 mL 0.1507 mL 0.3014 mL 0.7536 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Norfluoxetine hydrochloride
Cat. No.:
HY-W011235
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