Fluoxetine hydrochloride
Based on 46 publication(s) in Google Scholar
Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 56296-78-7
- Formula: C17H19ClF3NO
- Molecular Weight:345.79
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fluoxetine hydrochloride
More- Nat Med. 2019 Sep;25(9):1428-1441. [Abstract]
- Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
- Nat Commun. 2026 Jun 16. [Abstract]
- Adv Sci (Weinh). 2025 Jun 10:e01981. [Abstract]
- J Neuroinflammation. 2023 May 10;20(1):112. [Abstract]
- J Neuroinflammation. 2017 Oct 30;14(1):210. [Abstract]
- Phytomedicine. 2026 Apr:153:157934. [Abstract]
- Phytomedicine. 2025 Dec 8:150:157686. [Abstract]
- J Transl Med. 2024 Aug 22;22(1):785. [Abstract]
- Mol Med. 2026 Jun 13. [Abstract]
- Cell Rep. 2021 Nov 2;37(5):109957. [Abstract]
- Cell Prolif. 2021 Jan;54(1):e12953. [Abstract]
- Brain Behav Immun. 2026 Jan 26:134:106471. [Abstract]
- Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
- J Med Chem. 2026 Jun 11;69(11):13618-13634. [Abstract]
- Biochem Pharmacol. 2023 Nov:217:115846. [Abstract]
- Foods. 2026 Jun 21;15(12):2237. [Abstract]
- Eur J Pharmacol. 2026 Mar 28:1019:178713. [Abstract]
- Eur J Pharmacol. 2025 Dec 15:1009:178391. [Abstract]
- Eur J Pharmacol. 2019 Jan 15:843:260-267. [Abstract]
- Int Immunopharmacol. 2025 May 10:158:114821. [Abstract]
- Neurochem Int. 2026 Jul-Aug:197:106168. [Abstract]
- Gut Pathog. 2025 Aug 21;17(1):65. [Abstract]
- Neuropharmacology. 2021 Feb 15;184:108410. [Abstract]
- Biomedicines. 2023 Apr 26;11(5):1279. [Abstract]
- Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]
- Virol J. 2024 Aug 8;21(1):181. [Abstract]
- Neurotox Res. 2020 Dec;38(4):887-899. [Abstract]
- J Psychiatr Res. 2023 Oct 19:168:91-99. [Abstract]
- World J Biol Psychiatry. 2024 Nov 29:1-18. [Abstract]
- Reprod Toxicol. 2025 Jan 16:108840. [Abstract]
- Chem Biodivers. 2025 Sep 24:e00918. [Abstract]
- J Clin Psychopharmacol. 2021 Sep-Oct;41(5):525-533. [Abstract]
- Behav Brain Res. 2017 Jan 15:317:62-70. [Abstract]
- Fundam Clin Pharmacol. 2018 Aug;32(4):363-377. [Abstract]
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Behav Pharmacol. 2025 Apr 1;36(2-3):127-136. [Abstract]
- Behav Pharmacol. 2024 Jun 1;35(4):227-238. [Abstract]
- Behav Pharmacol. 2021 Feb 1;32(1):62-72. [Abstract]
- bioRxiv. 2026 May 29.
- Research Square Preprint. 2024 Dec 16.
- Orebro University. 2024.
- Preprints. 2023 Dec 27.
- Research Square Preprint. 2023 Jun 29.
- Research Square Preprint. 2023 Jun 16.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
Customer Validation & Images
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In Vivo Imaging
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In Vivo Efficacy Study
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IHC
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WB
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WB
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
150 nM
Compound: fluoxetine, prozac
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Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay
Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay
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[PMID: 22938049] |
| HEK293 | IC50 |
18400 nM
Compound: fluoxetine, prozac
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Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay
Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay
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[PMID: 22938049] |
| HEK293 | IC50 |
4410 nM
Compound: fluoxetine, prozac
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Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay
Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay
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[PMID: 22938049] |
| Spermatozoa | ED50 |
0.00007 %
Compound: Fluoxetine.HCl
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Spermicidal activity against human spermatozoa
Spermicidal activity against human spermatozoa
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[PMID: 16464584] |
Fluoxetine hydrochloride (LY 110140) blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell[1]. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex[2]. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus[3]. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56296-78-7
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Appearance Solid
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Molecular Weight 345.79
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Formula C17H19ClF3NO
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Color White to off-white
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SMILES
FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl
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Synonyms
LY 110140
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
Publications (46)
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Journal Impact Factor
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Most Recent
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Nat Med
2019 Sep;25(9):1428-1441. PMID: 31501614 -
Cell Metab
Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. [Abstract]2025 Dec 17:S1550-4131(25)00495-4. PMID: 41412121
Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
Ovarian cancer ID8 syngeneic model testing fluoxetine effect, Fluoxetine treatment (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest), Cisplatin (5 mg/kg, twice/week, intraperitoneal injection in indicated time windows). The figure shows representative bioluminescence imaging results.
Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]
Fluoxetine (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest). Ovarian cancer PDX #1795 mouse model treated with PARPi (Olaparib) alone or with a combination of Fluoxetine.
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Nat Commun
Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice. [Abstract]2026 Jun 16. PMID: 42303982 -
Adv Sci (Weinh)
The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress. [Abstract]2025 Jun 10:e01981. PMID: 40492401 -
J Neuroinflammation
The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice. [Abstract]2023 May 10;20(1):112. PMID: 37165444 -
J Neuroinflammation
Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. [Abstract]2017 Oct 30;14(1):210. PMID: 29084550 -
Phytomedicine
Sanhua essential oil exerts antidepressant effects in breast cancer-related depression by modulating metabolic pathways. [Abstract]2026 Apr:153:157934. PMID: 41722126 -
Phytomedicine
WenDan Decoction activates neuronal autophagy in the hippocampus via the gut-brain axis to improve depressive-like behavior in HFD mice. [Abstract]2025 Dec 8:150:157686. PMID: 41391369 -
J Transl Med
ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation. [Abstract]2024 Aug 22;22(1):785. PMID: 39175013 -
Mol Med
The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activation. [Abstract]2026 Jun 13. PMID: 42288765 -
Cell Rep
2021 Nov 2;37(5):109957. PMID: 34731610 -
Cell Prolif
Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin. [Abstract]2021 Jan;54(1):e12953. PMID: 33211371 -
Brain Behav Immun
Depression-related chronic stress promotes ovarian cancer progression via metabolic dysfunction and IRF1-mediated immune suppression. [Abstract]2026 Jan 26:134:106471. PMID: 41605304 -
Brain Behav Immun
Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. [Abstract]2021 Jul:95:142-153. PMID: 33737174
Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
Fluoxetine (20 mg/kg; ip). Representative images of DCX positive cells in the DG of hippocampus in different group.
Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]
Fluoxetine (20 mg/kg; ip). Representative immunoblots of DCX and NeuN expression levels in different groups.
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J Med Chem
Development of Novel Estradiol-Indole Hybrids Targeting SERT and ERβ as Potential Antidepressants. [Abstract]2026 Jun 11;69(11):13618-13634. PMID: 42154662 -
Biochem Pharmacol
Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms. [Abstract]2023 Nov:217:115846. PMID: 37804870 -
Foods
Fermented Dendrobium officinale Ameliorates Sleep Deprivation-Induced Depressive-like Behaviors by Attenuating Neuroinflammation and Restoring 5-HT Synthesis via the Gut-Brain Axis. [Abstract]2026 Jun 21;15(12):2237. PMID: 42354205 -
Eur J Pharmacol
Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice. [Abstract]2026 Mar 28:1019:178713. PMID: 41794274 -
Eur J Pharmacol
Gypenoside XVII regulates apoptosis and fear extinction deficits mediated by post-traumatic stress disorder through the PERK/CHOP signaling pathway. [Abstract]2025 Dec 15:1009:178391. PMID: 41276105 -
Eur J Pharmacol
2019 Jan 15:843:260-267. PMID: 30502341 -
Int Immunopharmacol
Fucosterol ameliorates depressive-like behaviours by suppressing microglial activation and neuroinflammation via inhibition the MAPK/ERK1/2 signaling pathway. [Abstract]2025 May 10:158:114821. PMID: 40349406 -
Neurochem Int
Targeted stabilization of astrocytic Cx43 gap junctions reverses depression-like behaviors via dual restoration of syncytial networks and glutamatergic homeostasis. [Abstract]2026 Jul-Aug:197:106168. PMID: 42102929 -
Gut Pathog
Lactobacillus reuteri DSM 17,938 ameliorates LPS-induced depression-like and anxiety-like behaviors by modulating gut microbiota and brain metabolic function. [Abstract]2025 Aug 21;17(1):65. PMID: 40841920 -
Neuropharmacology
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress. [Abstract]2021 Feb 15;184:108410. PMID: 33242526 -
Biomedicines
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation. [Abstract]2023 Apr 26;11(5):1279. PMID: 37238950 -
Prog Neuropsychopharmacol Biol Psychiatry
2017 Jun 15;79(Pt B):258-267. PMID: 28625859
Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]
Representative images showing the restoration effect of harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg; ip) was used as a positive control, and all data were shown as mean ± SEM.
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Virol J
2024 Aug 8;21(1):181. PMID: 39118175 -
Neurotox Res
Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice. [Abstract]2020 Dec;38(4):887-899. PMID: 32588356 -
J Psychiatr Res
2023 Oct 19:168:91-99. PMID: 39492237 -
World J Biol Psychiatry
SEP-363856 attenuates CUMS-induced depression-like behaviours and reverses hippocampal neuronal injuries. [Abstract]2024 Nov 29:1-18. PMID: 39610275 -
Reprod Toxicol
Long-term Oral Fluoxetine Leads to Reduced Male Reproductive Function in Mice and Gradual Recovery After Discontinuation. [Abstract]2025 Jan 16:108840. PMID: 39826770 -
Chem Biodivers
New 2,3-Methylenedioxy-naphthalene Derivatives With Neuroprotective Activity From the Roots of Ephedra sinica Stapf. [Abstract]2025 Sep 24:e00918. PMID: 40991575 -
J Clin Psychopharmacol
Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. [Abstract]2021 Sep-Oct;41(5):525-533. PMID: 34121064 -
Behav Brain Res
Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?. [Abstract]2017 Jan 15:317:62-70. PMID: 27633560 -
Fundam Clin Pharmacol
Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress. [Abstract]2018 Aug;32(4):363-377. PMID: 29578616 -
Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
Behav Pharmacol
Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. [Abstract]2025 Apr 1;36(2-3):127-136. PMID: 39611623 -
Behav Pharmacol
2024 Jun 1;35(4):227-238. PMID: 38651981 -
Behav Pharmacol
Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. [Abstract]2021 Feb 1;32(1):62-72. PMID: 33416256 -
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Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvent & Solubility
DMSO : ≥ 25 mg/mL (72.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 8.33 mg/mL (24.09 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (5.78 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (72.30 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
Male Sprague-Dawley rats weighing 250-300 g are housed under a 12-hour light/12-hour dark cycle (lights on at 7:00 am, lights off at 7:00 pm) and at constant temperature (25°C) and humidity and allowed free access to food and water. For chronic drug treatments, rats are administered fluoxetine (5 mg/kg/day) or saline by intraperitoneal (IP) injection once daily and olanzapine or vehicle in the drinking water for 21 days (vehicle-treated control, fluoxetine, and olanzapine alone) plus the combination of fluoxetine and olanzapine. For combination treatment, olanzapine is chosen because fluoxetine is known to interfere with the metabolism of olanzapine and raise the blood levels by up to 4-6 times. Olanzapine is dissolved in hydrochloric acid (HCl), then adjusted back to pH 6 with 1 N sodium hydroxide to make the stock solution of 3 mg/mL concentration. The same amount of vehicle solution is added to the water for the control animals. Fluid intake is measured three times per week, and drinking bottles are replenwashed with fresh drug solution. There are no differences in fluid intake among the treatment groups. For subchronic treatment, drugs are administered exactly the same way but for a total period of 7 days.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (620 KB)
- English - EN (620 KB)
- Français - FR (620 KB)
- Deutsch - DE (620 KB)
- Norwegian - NO (620 KB)
- Español - ES (620 KB)
- Swedish - SV (620 KB)
- Italian - IT (620 KB)
- Korean - KR (620 KB)
- Portuguese - PT (620 KB)
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Handling Instructions (2659 KB)
References
[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [Content Brief]
[2]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [Content Brief]
[3]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [Content Brief]
[4]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [Content Brief]
[5]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [Content Brief]
[6]. Su WJ, et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14(1):210. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.8919 mL | 14.4596 mL | 28.9193 mL | 72.2982 mL |
| 5 mM | 0.5784 mL | 2.8919 mL | 5.7839 mL | 14.4596 mL | |
| 10 mM | 0.2892 mL | 1.4460 mL | 2.8919 mL | 7.2298 mL | |
| 15 mM | 0.1928 mL | 0.9640 mL | 1.9280 mL | 4.8199 mL | |
| 20 mM | 0.1446 mL | 0.7230 mL | 1.4460 mL | 3.6149 mL | |
| DMSO | 25 mM | 0.1157 mL | 0.5784 mL | 1.1568 mL | 2.8919 mL |
| 30 mM | 0.0964 mL | 0.4820 mL | 0.9640 mL | 2.4099 mL | |
| 40 mM | 0.0723 mL | 0.3615 mL | 0.7230 mL | 1.8075 mL | |
| 50 mM | 0.0578 mL | 0.2892 mL | 0.5784 mL | 1.4460 mL | |
| 60 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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