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Cat. No.: HY-N8796

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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines.

For research use only. We do not sell to patients.

Purity: 96.09%
CAS No.: 75679-58-2
Formula: C₁₇H₁₈O₅
Molecular Weight:302.32

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Chemical Structure

CAS No.: 75679-58-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	>206 μM Compound: 1	Cytotoxicity against human DU145 cells after 48 hrs Cytotoxicity against human DU145 cells after 48 hrs	[PMID: 18798609]
DU-145	GI₅₀	137.9 μM Compound: 4	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 19199646]
DU-145	GI₅₀	41.7 μg/mL Compound: 6	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 18163590]
HT-29	GI₅₀	>206 μM Compound: 1	Cytotoxicity against human HT29 cells after 48 hrs Cytotoxicity against human HT29 cells after 48 hrs	[PMID: 18798609]
HT-29	GI₅₀	117.4 μM Compound: 4	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 19199646]
HT-29	GI₅₀	35.5 μg/mL Compound: 6	Cytotoxicity against human HT29 cells Cytotoxicity against human HT29 cells	[PMID: 18163590]
K562	GI₅₀	22.8 μM Compound: 1	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 18798609]
K562	GI₅₀	24.5 μM Compound: 4	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 19199646]
K562	GI₅₀	7.4 μg/mL Compound: 6	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18163590]
M14	GI₅₀	109.2 μM Compound: 1	Cytotoxicity against human M14 cells after 48 hrs Cytotoxicity against human M14 cells after 48 hrs	[PMID: 18798609]
M14	GI₅₀	133.3 μM Compound: 4	Cytotoxicity against human M14 cells Cytotoxicity against human M14 cells	[PMID: 19199646]
M14	GI₅₀	40.3 μg/mL Compound: 6	Cytotoxicity against human M14 cells Cytotoxicity against human M14 cells	[PMID: 18163590]
MCF7	GI₅₀	22.9 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 18163590]
MCF7	GI₅₀	65.5 μM Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs	[PMID: 18798609]
MCF7	GI₅₀	75.7 μM Compound: 4	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 19199646]
NCI-H460	GI₅₀	128 μM Compound: 1	Cytotoxicity against human H460 cells after 48 hrs Cytotoxicity against human H460 cells after 48 hrs	[PMID: 18798609]
NCI-H460	GI₅₀	147.9 μM Compound: 4	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 19199646]
NCI-H460	GI₅₀	44.7 μg/mL Compound: 6	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 18163590]
NIH3T3	GI₅₀	>206 μM Compound: 1	Cytotoxicity against BALB mouse 3T3 cells after 48 hrs Cytotoxicity against BALB mouse 3T3 cells after 48 hrs	[PMID: 18798609]
NIH3T3	GI₅₀	140.6 μM Compound: 4	Cytotoxicity against mouse 3T3 cells Cytotoxicity against mouse 3T3 cells	[PMID: 19199646]
NIH3T3	GI₅₀	42.5 μg/mL Compound: 6	Cytotoxicity against BALB/c mouse 3T3 cells Cytotoxicity against BALB/c mouse 3T3 cells	[PMID: 18163590]
PC-3	GI₅₀	153.1 μM Compound: 4	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 19199646]
PC-3	GI₅₀	46.3 μg/mL Compound: 6	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 18163590]
PC-3	GI₅₀	59.9 μM Compound: 1	Cytotoxicity against human PC3 cells after 48 hrs Cytotoxicity against human PC3 cells after 48 hrs	[PMID: 18798609]
Vero	GI₅₀	133.6 μM Compound: 4	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 19199646]
Vero	GI₅₀	40.4 μg/mL Compound: 6	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 18163590]
Vero	IC₅₀	>25 μM Compound: 1	Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs	[PMID: 18798609]

Chemical Information

CAS No. 75679-58-2
Appearance Solid
Molecular Weight 302.32
Formula C₁₇H₁₈O₅
Color White to off-white
SMILES

O=C(C1=C(OC)C=C(O)C=C1O)CCC2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aponte JC, et al. Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones. J Med Chem. 2008;51(19):6230-6234. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

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Biological Activity
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References

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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Related Classifications

HY-N8796 Related Classifications