2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone 

Cat. No.: HY-N8796 Purity: 96.09%
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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines.

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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Chemical Structure

CAS No. : 75679-58-2

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Based on 1 publication(s) in Google Scholar

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Related Antibodies

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Description

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines[1].

Cellular Effect
Cell Line Type Value Description References
DU-145 GI50
137.9 μM
Compound: 4
Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
[PMID: 19199646]
DU-145 GI50
41.7 μg/mL
Compound: 6
Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
[PMID: 18163590]
DU-145 GI50
> 206 μM
Compound: 1
Cytotoxicity against human DU145 cells after 48 hrs
Cytotoxicity against human DU145 cells after 48 hrs
[PMID: 18798609]
HT-29 GI50
117.4 μM
Compound: 4
Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
[PMID: 19199646]
HT-29 GI50
35.5 μg/mL
Compound: 6
Cytotoxicity against human HT29 cells
Cytotoxicity against human HT29 cells
[PMID: 18163590]
HT-29 GI50
> 206 μM
Compound: 1
Cytotoxicity against human HT29 cells after 48 hrs
Cytotoxicity against human HT29 cells after 48 hrs
[PMID: 18798609]
K562 GI50
22.8 μM
Compound: 1
Cytotoxicity against human K562 cells after 48 hrs
Cytotoxicity against human K562 cells after 48 hrs
[PMID: 18798609]
K562 GI50
24.5 μM
Compound: 4
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 19199646]
K562 GI50
7.4 μg/mL
Compound: 6
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 18163590]
M14 GI50
109.2 μM
Compound: 1
Cytotoxicity against human M14 cells after 48 hrs
Cytotoxicity against human M14 cells after 48 hrs
[PMID: 18798609]
M14 GI50
133.3 μM
Compound: 4
Cytotoxicity against human M14 cells
Cytotoxicity against human M14 cells
[PMID: 19199646]
M14 GI50
40.3 μg/mL
Compound: 6
Cytotoxicity against human M14 cells
Cytotoxicity against human M14 cells
[PMID: 18163590]
MCF7 GI50
22.9 μg/mL
Compound: 6
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 18163590]
MCF7 GI50
65.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 48 hrs
Cytotoxicity against human MCF7 cells after 48 hrs
[PMID: 18798609]
MCF7 GI50
75.7 μM
Compound: 4
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 19199646]
NCI-H460 GI50
128 μM
Compound: 1
Cytotoxicity against human H460 cells after 48 hrs
Cytotoxicity against human H460 cells after 48 hrs
[PMID: 18798609]
NCI-H460 GI50
147.9 μM
Compound: 4
Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
[PMID: 19199646]
NCI-H460 GI50
44.7 μg/mL
Compound: 6
Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
[PMID: 18163590]
NIH3T3 GI50
140.6 μM
Compound: 4
Cytotoxicity against mouse 3T3 cells
Cytotoxicity against mouse 3T3 cells
[PMID: 19199646]
NIH3T3 GI50
42.5 μg/mL
Compound: 6
Cytotoxicity against BALB/c mouse 3T3 cells
Cytotoxicity against BALB/c mouse 3T3 cells
[PMID: 18163590]
NIH3T3 GI50
> 206 μM
Compound: 1
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
[PMID: 18798609]
PC-3 GI50
153.1 μM
Compound: 4
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
[PMID: 19199646]
PC-3 GI50
46.3 μg/mL
Compound: 6
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
[PMID: 18163590]
PC-3 GI50
59.9 μM
Compound: 1
Cytotoxicity against human PC3 cells after 48 hrs
Cytotoxicity against human PC3 cells after 48 hrs
[PMID: 18798609]
Vero GI50
133.6 μM
Compound: 4
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
[PMID: 19199646]
Vero GI50
40.4 μg/mL
Compound: 6
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
[PMID: 18163590]
Vero IC50
> 25 μM
Compound: 1
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
[PMID: 18798609]
Molecular Weight

302.32

Formula

C17H18O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(OC)C=C(O)C=C1O)CCC2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone75679-58-2Endogenous Metabolitedihydrochalconecytotoxic metabolitecancerInhibitorinhibitorinhibit

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