Arcyriaflavin A
Based on 1 Customer Validation
Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor. Arcyriaflavin A exists in the marine ascidian Eudistoma sp. and the slime mold Arcyria denudata. Arcyriaflavin A is applicable to research related to colon cancer and lung cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.8%
- CAS No.: 118458-54-1
- Formule: C20H11N3O2
- Masse moléculaire:325.32
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
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Cdk4/cyclin D1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
>100 μM
Compound: 14
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Antiproliferative activity against B16 mouse melanoma cells
Antiproliferative activity against B16 mouse melanoma cells
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[PMID: 8893841] |
| HCT-116 | IC50 |
0.85 μM
Compound: 2 (Arcyiaflavin A)
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In vitro antiproliferative activity against human carcinoma cell line HCT116 (colon)
In vitro antiproliferative activity against human carcinoma cell line HCT116 (colon)
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[PMID: 12824014] |
| HCT-116 | IC50 |
0.85 μM
Compound: 3
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Inhibition of human HCT(colon) carcinoma cell proliferation
Inhibition of human HCT(colon) carcinoma cell proliferation
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[PMID: 14552791] |
| HCT-116 | IC50 |
0.85 μM
Compound: 4a
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In vitro antiproliferative activity against HCT116 ( human colon) cell line.
In vitro antiproliferative activity against HCT116 ( human colon) cell line.
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[PMID: 14552792] |
| HCT-116 | IC50 |
0.85 μM
Compound: 4a (Arcyriaflavin A)
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Inhibition of cell growth of HCT116 tumor cell lines
Inhibition of cell growth of HCT116 tumor cell lines
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[PMID: 12747775] |
| NCI-H460 | IC50 |
0.59 μM
Compound: 2 (Arcyiaflavin A)
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In vitro antiproliferative activity against human carcinoma cell line H460 (lung)
In vitro antiproliferative activity against human carcinoma cell line H460 (lung)
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[PMID: 12824014] |
| NCI-H460 | IC50 |
0.59 μM
Compound: 3
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Inhibition of human NCI-H460 (lung) carcinoma cell proliferation
Inhibition of human NCI-H460 (lung) carcinoma cell proliferation
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[PMID: 14552791] |
| NCI-H460 | IC50 |
0.59 μM
Compound: 4a
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In vitro antiproliferative activity against NCI-460 (human lung) cell line.
In vitro antiproliferative activity against NCI-460 (human lung) cell line.
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[PMID: 14552792] |
| NCI-H460 | IC50 |
0.59 μM
Compound: 4a (Arcyriaflavin A)
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Inhibition of cell growth of NCI-H460 tumor cell lines
Inhibition of cell growth of NCI-H460 tumor cell lines
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[PMID: 12747775] |
| P388 | IC50 |
4 μM
Compound: 14
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Antiproliferative activity against P388 Murine Leukemia cells
Antiproliferative activity against P388 Murine Leukemia cells
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[PMID: 8893841] |
| Sf9 | IC50 |
>20 μM
Compound: Arcyriaflavin A
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Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
| Sf9 | IC50 |
>20 μM
Compound: Arcyriaflavin A
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Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
| Sf9 | IC50 |
0.199 μM
Compound: Arcyriaflavin A
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Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
| Sf9 | IC50 |
0.534 μM
Compound: Arcyriaflavin A
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Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
| Sf9 | IC50 |
0.936 μM
Compound: Arcyriaflavin A
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Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
| Sf9 | IC50 |
0.964 μM
Compound: Arcyriaflavin A
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Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
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[PMID: 30234987] |
In Vitro
Arcyriaflavin A (series concentration, 24h) shows good inhibitory activity (IC 50 =140 nM) for D1–CDK4.
Arcyriaflavin A demonstrates strated significantly improved selectivity towards D1–CDK4 than several other kinases (B–CDK1, E–CDK2, PKA, and PKC.
Arcyriaflavin A (series concentration, 24h) inhibits cell proliferation with IC50 values of 0.84 μM and 059 μM towards HCT116 and NCI-H460 cell lines.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 118458-54-1
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Appearance Solid
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Masse moléculaire 325.32
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Formule C20H11N3O2
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Color Brown to reddish brown
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SMILES
O=C1NC(C2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (76.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (345 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Horton PA, et al. Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. Experientia. 1994;50(9):843-845. [Content Brief]
[2]. Sanchez-Martinez C, et al. Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg Med Chem Lett. 2003;13(21):3835-3839. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0739 mL | 15.3695 mL | 30.7390 mL | 76.8474 mL |
| 5 mM | 0.6148 mL | 3.0739 mL | 6.1478 mL | 15.3695 mL | |
| 10 mM | 0.3074 mL | 1.5369 mL | 3.0739 mL | 7.6847 mL | |
| 15 mM | 0.2049 mL | 1.0246 mL | 2.0493 mL | 5.1232 mL | |
| 20 mM | 0.1537 mL | 0.7685 mL | 1.5369 mL | 3.8424 mL | |
| 25 mM | 0.1230 mL | 0.6148 mL | 1.2296 mL | 3.0739 mL | |
| 30 mM | 0.1025 mL | 0.5123 mL | 1.0246 mL | 2.5616 mL | |
| 40 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9212 mL | |
| 50 mM | 0.0615 mL | 0.3074 mL | 0.6148 mL | 1.5369 mL | |
| 60 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL | 1.2808 mL |
Arcyriaflavin A Related Classifications
HY-103382 Related Classifications
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