1. Apoptosis
    Stem Cell/Wnt
    Protein Tyrosine Kinase/RTK
    NF-κB
    Anti-infection
  2. Apoptosis
    PKA
    NF-κB
    Bacterial
    Fungal
    Antibiotic
  3. Gliotoxin

Gliotoxin (Synonyms: Aspergillin)

Cat. No.: HY-N6727 Purity: >98.0%
Handling Instructions

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.

For research use only. We do not sell to patients.

Gliotoxin Chemical Structure

Gliotoxin Chemical Structure

CAS No. : 67-99-2

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Description

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1]. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells[3].

Molecular Weight

326.39

Formula

C₁₃H₁₄N₂O₄S₂

CAS No.

67-99-2

SMILES

O=C1N(C)[[email protected]@]2(CO)C(N3[[email protected]@]1(SS2)CC4=CC=C[[email protected]](O)[[email protected]@]34[H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

GliotoxinAspergillinApoptosisPKANF-κBBacterialFungalAntibioticProtein kinase ANuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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