1-Palmitoyl-2-oleoyl-sn-glycerol

Name: 1-Palmitoyl-2-oleoyl-sn-glycerol
Brand: MedChemExpress
SKU: HY-134200
Rating: 4.5 (0 reviews)

Cat. No.: HY-134200 Pureza: 99.56%: Ficha de datos
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1-Palmitoyl-2-oleoyl-sn-glycerol is a diacylglycerol hormogonium inducer that can be isolated from the coralloid roots of Cycas revoluta. 1-Palmitoyl-2-oleoyl-sn-glycerol promotes the differentiation of filamentous Nostoc cell aggregates into motile hormogonia, and further induces the formation of dense bundle-like structures. 1-Palmitoyl-2-oleoyl-sn-glycerol is not only commonly used as a diacylglycerol standard, but also can effectively identify and separate glycerophosphate-containing phospholipid enantiomers after acetylation. 1-Palmitoyl-2-oleoyl-sn-glycerol is also used to study cyanobacterial developmental mechanisms and lipid analysis.

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1-Palmitoyl-2-oleoyl-sn-glycerol Estructura química

No. CAS : 29541-66-0

Tamaño	Stock	Cantidad
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Liquid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Pureza y Documentación
Referencias
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Descripciòn

IC₅₀ & Target

Hormogonium-inducing factor^[1]

In Vitro

1-Palmitoyl-2-oleoyl-sn-glycerol (10 pmol/disc-100 nmol/disc) shows potent hormogonium-inducing activity toward Nostoc sp. strain Yaku-1, with maximum activity at 100 and 10 nmol/disc rated as (++), maintained activity rated as (+) at 1 nmol/disc, (±) at 100 pmol/disc, and no activity at 10 pmol/disc^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

594.95

Fòrmula

C₃₇H₇₀O₅

No. CAS

29541-66-0

Appearance

Liquid (Density: 0.932±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](CO)COC(CCCCCCCCCCCCCCC)=O)=O

Initial Source

Endogenous metabolite

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (168.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6808 mL	8.4041 mL	16.8081 mL
5 mM	0.3362 mL	1.6808 mL	3.3616 mL
10 mM	0.1681 mL	0.8404 mL	1.6808 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.10 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (2.10 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.90%

Select Batch:

Ficha de datos (266 KB) SDS (587 KB)

COA (237 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Rezanka T, Palyzová A, Vítová M, et al. Structural Characterization of Mono-and Dimethylphosphatidylethanolamines from Various Organisms Using a Complex Analytical Strategy including Chiral Chromatography. Symmetry 2022, 14, 616[EB/OL].(2022)

[2]. Hashidoko Y, et al. Isolation and characterization of 1-palmitoyl-2-linoleoyl-sn-glycerol as a hormogonium-inducing factor (HIF) from the coralloid roots of Cycas revoluta (Cycadaceae). Sci Rep. 2019;9(1):4751. Published 2019 Mar 18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6808 mL	8.4041 mL	16.8081 mL	42.0203 mL
	5 mM	0.3362 mL	1.6808 mL	3.3616 mL	8.4041 mL
	10 mM	0.1681 mL	0.8404 mL	1.6808 mL	4.2020 mL
	15 mM	0.1121 mL	0.5603 mL	1.1205 mL	2.8014 mL
	20 mM	0.0840 mL	0.4202 mL	0.8404 mL	2.1010 mL
	25 mM	0.0672 mL	0.3362 mL	0.6723 mL	1.6808 mL
	30 mM	0.0560 mL	0.2801 mL	0.5603 mL	1.4007 mL
	40 mM	0.0420 mL	0.2101 mL	0.4202 mL	1.0505 mL
	50 mM	0.0336 mL	0.1681 mL	0.3362 mL	0.8404 mL
	60 mM	0.0280 mL	0.1401 mL	0.2801 mL	0.7003 mL
	80 mM	0.0210 mL	0.1051 mL	0.2101 mL	0.5253 mL
	100 mM	0.0168 mL	0.0840 mL	0.1681 mL	0.4202 mL