N-Demethyl Ivabradine hydrochloride
Based on 1 Customer Validation
N-Demethyl Ivabradine (hydrochloride) is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.
For research use only. We do not sell to patients.
- Purity : 99.63%
- CAS No.: 1246638-08-3
- Formula: C26H35ClN2O5
- Molecular Weight:491.02
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-12778R
Ivabradine metabolite N-Demethyl Ivabradine hydrochloride (Standard) -
HY-100599
Urolithin A -
HY-10873
N-Desethyl Sunitinib -
HY-G0005
Duloxetine metabolite Para-Naphthol Duloxetine -
HY-B1103
Hydroxyhexamide -
HY-G0004
Acetaminophen metabolite 3-hydroxy-acetaminophen -
HY-10873R
N-Desethyl Sunitinib (Standard) -
HY-G0023
Niraparib metabolite M1 -
HY-G0003
Iloperidone metabolite Hydroxy Iloperidone -
HY-100599R
Urolithin A (Standard) -
HY-G0004R
Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard) -
HY-B1103R
Hydroxyhexamide (Standard)
Biological Activity
Description
Chemical Information
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CAS No. 1246638-08-3
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Appearance Solid
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Molecular Weight 491.02
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Formula C26H35ClN2O5
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Color White to off-white
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SMILES
O=C1N(CCCNC[C@@H]2C(C=C(OC)C(OC)=C3)=C3C2)CCC4=CC(OC)=C(OC)C=C4C1.Cl
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Synonyms
Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 66.67 mg/mL (135.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (242 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0366 mL | 10.1829 mL | 20.3658 mL | 50.9144 mL |
| 5 mM | 0.4073 mL | 2.0366 mL | 4.0732 mL | 10.1829 mL | |
| 10 mM | 0.2037 mL | 1.0183 mL | 2.0366 mL | 5.0914 mL | |
| 15 mM | 0.1358 mL | 0.6789 mL | 1.3577 mL | 3.3943 mL | |
| 20 mM | 0.1018 mL | 0.5091 mL | 1.0183 mL | 2.5457 mL | |
| 25 mM | 0.0815 mL | 0.4073 mL | 0.8146 mL | 2.0366 mL | |
| 30 mM | 0.0679 mL | 0.3394 mL | 0.6789 mL | 1.6971 mL | |
| 40 mM | 0.0509 mL | 0.2546 mL | 0.5091 mL | 1.2729 mL | |
| 50 mM | 0.0407 mL | 0.2037 mL | 0.4073 mL | 1.0183 mL | |
| 60 mM | 0.0339 mL | 0.1697 mL | 0.3394 mL | 0.8486 mL | |
| 80 mM | 0.0255 mL | 0.1273 mL | 0.2546 mL | 0.6364 mL | |
| 100 mM | 0.0204 mL | 0.1018 mL | 0.2037 mL | 0.5091 mL |
N-Demethyl Ivabradine hydrochloride Related Classifications
HY-12778 Related Classifications
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