Ivabradine hydrochloride

Cat. No.: HY-B0162A Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.

For research use only. We do not sell to patients.

Ivabradine hydrochloride Chemical Structure

CAS No. : 148849-67-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 209	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 374	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 671	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Ivabradine hydrochloride:

Ivabradine metabolite N-Demethyl Ivabradine hydrochloride In-stock
Ivabradine-d₆ hydrochloride In-stock
Ivabradine Get quote
Ivabradine-d₃ hydrochloride Get quote
Ivabradine-d₆ Get quote

2 Publications Citing Use of MCE Ivabradine hydrochloride

: Ivabradine hydrochloride purchased from MCE. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936. [Abstract]; Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Ivabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice^[3].
Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	25-30 g, 6 weeks male Swiss mice^[3]
Dosage:	1, 10, 20 mg/kg
Administration:	I.p.; for 3 days
Result:	Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.

Animal Model:	3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR^[4]
Dosage:	5, 10, 20 mg/kg
Administration:	P.o; daily for 1 weeks
Result:	Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.

Clinical Trial

Molecular Weight

505.05

Appearance

Solid

Formula

C₂₇H₃₇ClN₂O₅

CAS No.

148849-67-6

SMILES

O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (99.00 mM; Need ultrasonic)

DMSO : 25 mg/mL (49.50 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9800 mL	9.9000 mL	19.8000 mL
5 mM	0.3960 mL	1.9800 mL	3.9600 mL
10 mM	0.1980 mL	0.9900 mL	1.9800 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS
Solubility: 50 mg/mL (99.00 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (247 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36. [Content Brief]

[2]. Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105. [Content Brief]

[3]. Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512. [Content Brief]

[4]. Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12. [Content Brief]