Ivabradine hydrochloride
Based on 3 publication(s) in Google Scholar
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 148849-67-6
- Formula: C27H37ClN2O5
- Molecular Weight:505.05
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Ivabradine hydrochloride
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:25-30 g, 6 weeks male Swiss mice[3]
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Dosage:1, 10, 20 mg/kg
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Administration:I.p.; for 3 days
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Result:Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.
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Animal Model:3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR[4]
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Dosage:5, 10, 20 mg/kg
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Administration:P.o; daily for 1 weeks
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Result:Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 148849-67-6
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Appearance Solid
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Molecular Weight 505.05
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Formula C27H37ClN2O5
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Color White to off-white
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SMILES
O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Front Pharmacol
Ivabradine Ameliorates Cardiac Diastolic Dysfunction in Diabetic Mice Independent of Heart Rate Reduction. [Abstract]2021 Jun 22:12:696635. PMID: 34239443
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
NRCFs were pretreated with or without Ivabradine (10-40 μM) at the indicated concentrations for 30 min, and then exposed to HG for 48 h. JNK and p38 MAPK phosphorylation and total JNK and p38 MAPK expression were determined by western blotting.
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
NRCFs were treated with or without ivabradine at the indicated concentrations for 30 min, and then exposed to HG for 48 h. The protein expression of PCNA, α-SMA, TIMP2, collagen I, collagen III, and MMP2 was determined by western blotting.
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
NRCFs were treated with or without ivabradine at the indicated concentrations for 30 min, and then exposed to HG for 48 h. The cell proliferation rate was determined using an MTT assay.
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
Effects of ivabradine and zatebradine on heart rate (HR) and biometric parameters. During treatment with or without Ivabradine (20 mg/kg) for 7–11 weeks, the mean HR of mice was recorded by electrocardiography (ECG).
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
Mice were treated with or without Ivabradine (20 mg/kg) for 7–11 weeks, and their blood glucose concentration was measured.
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 22:12:696635. [Abstract]
Mice were treated with or without Ivabradine (20 mg/kg) for 7–11 weeks, and their body mass was measured.
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J Cell Physiol
Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy. [Abstract]2019 Feb;234(2):1925-1936. PMID: 30067872
Ivabradine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936. [Abstract]
Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.
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Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
Solvent & Solubility
H2O : 50 mg/mL (99.00 mM; Need ultrasonic)
DMSO : 25 mg/mL (49.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (99.00 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (458 KB)
- English - EN (458 KB)
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- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
References
[1]. Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36. [Content Brief]
[2]. Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105. [Content Brief]
[3]. Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512. [Content Brief]
[4]. Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 1.9800 mL | 9.9000 mL | 19.8000 mL | 49.5001 mL |
| 5 mM | 0.3960 mL | 1.9800 mL | 3.9600 mL | 9.9000 mL | |
| 10 mM | 0.1980 mL | 0.9900 mL | 1.9800 mL | 4.9500 mL | |
| 15 mM | 0.1320 mL | 0.6600 mL | 1.3200 mL | 3.3000 mL | |
| 20 mM | 0.0990 mL | 0.4950 mL | 0.9900 mL | 2.4750 mL | |
| 25 mM | 0.0792 mL | 0.3960 mL | 0.7920 mL | 1.9800 mL | |
| 30 mM | 0.0660 mL | 0.3300 mL | 0.6600 mL | 1.6500 mL | |
| 40 mM | 0.0495 mL | 0.2475 mL | 0.4950 mL | 1.2375 mL | |
| H2O | 50 mM | 0.0396 mL | 0.1980 mL | 0.3960 mL | 0.9900 mL |
| 60 mM | 0.0330 mL | 0.1650 mL | 0.3300 mL | 0.8250 mL | |
| 80 mM | 0.0248 mL | 0.1238 mL | 0.2475 mL | 0.6188 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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