1. Membrane Transporter/Ion Channel
  2. HCN Channel
  3. Ivabradine hydrochloride

Ivabradine hydrochloride 

Cat. No.: HY-B0162A Purity: 99.61%
COA Handling Instructions

Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.

For research use only. We do not sell to patients.

Ivabradine hydrochloride Chemical Structure

Ivabradine hydrochloride Chemical Structure

CAS No. : 148849-67-6

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 55 In-stock
50 mg USD 209 In-stock
100 mg USD 374 In-stock
200 mg USD 671 In-stock
500 mg   Get quote  
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Ivabradine hydrochloride:

Top Publications Citing Use of Products

    Ivabradine hydrochloride purchased from MCE. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936.  [Abstract]

    Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

    In Vivo

    Ivabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice[3].
    Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 25-30 g, 6 weeks male Swiss mice[3]
    Dosage: 1, 10, 20 mg/kg
    Administration: I.p.; for 3 days
    Result: Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.
    Animal Model: 3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR[4]
    Dosage: 5, 10, 20 mg/kg
    Administration: P.o; daily for 1 weeks
    Result: Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.
    Clinical Trial
    Molecular Weight

    505.05

    Appearance

    Solid

    Formula

    C27H37ClN2O5

    CAS No.
    SMILES

    O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (99.00 mM; Need ultrasonic)

    DMSO : 25 mg/mL (49.50 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9800 mL 9.9000 mL 19.8000 mL
    5 mM 0.3960 mL 1.9800 mL 3.9600 mL
    10 mM 0.1980 mL 0.9900 mL 1.9800 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (99.00 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Ivabradine hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Ivabradine hydrochloride
    Cat. No.:
    HY-B0162A
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