1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Ivabradine hydrochloride

Ivabradine hydrochloride 

Cat. No.: HY-B0162A Purity: 99.87%
Handling Instructions

Ivabradine hydrochloride is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.

For research use only. We do not sell to patients.

Ivabradine hydrochloride Chemical Structure

Ivabradine hydrochloride Chemical Structure

CAS No. : 148849-67-6

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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50 mg USD 190 In-stock
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100 mg USD 340 In-stock
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200 mg USD 610 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Ivabradine hydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Ivabradine hydrochloride

    Ivabradine hydrochloride purchased from MCE. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936.

    Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.
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    Description

    Ivabradine hydrochloride is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.

    In Vivo

    Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2].

    Clinical Trial
    Molecular Weight

    505.05

    Formula

    C₂₇H₃₇ClN₂O₅

    CAS No.

    148849-67-6

    SMILES

    O=C1N(CCCN(C[[email protected]@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 51 mg/mL (100.98 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9800 mL 9.9000 mL 19.8000 mL
    5 mM 0.3960 mL 1.9800 mL 3.9600 mL
    10 mM 0.1980 mL 0.9900 mL 1.9800 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    IvabradineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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    Product name:
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    Cat. No.:
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