1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Niraparib metabolite M1

Niraparib metabolite M1 (Synonyms: Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib)

Cat. No.: HY-G0023 Purity: 99.85%
Handling Instructions

Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

For research use only. We do not sell to patients.

Niraparib metabolite M1 Chemical Structure

Niraparib metabolite M1 Chemical Structure

CAS No. : 1476777-06-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 467 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 660 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Niraparib metabolite M1:

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Description

Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

In Vitro

Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study[1].

Molecular Weight

321.37

Formula

C₁₉H₁₉N₃O₂

CAS No.

1476777-06-6

SMILES

O=C(C1=CC=CC2=CN(C3=CC=C([[email protected]]4CNCCC4)C=C3)N=C12)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (311.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1117 mL 15.5584 mL 31.1168 mL
5 mM 0.6223 mL 3.1117 mL 6.2234 mL
10 mM 0.3112 mL 1.5558 mL 3.1117 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (8.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (8.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (8.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Niraparib metabolite M1
Cat. No.:
HY-G0023
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