1. GPCR/G Protein
  2. P2Y Receptor
  3. Prasugrel

Prasugrel (Synonyms: PCR 4099)

Cat. No.: HY-15284 Purity: >98.0%
Handling Instructions

Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.

For research use only. We do not sell to patients.

Prasugrel Chemical Structure

Prasugrel Chemical Structure

CAS No. : 150322-43-3

Size Price Stock Quantity
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
500 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].

IC50 & Target

P2Y12 receptor[1]

In Vivo

In rat platelets, Prasugrel active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC50 value of 1.8 μM[2].
Prasugrel acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

373.44

Formula

C₂₀H₂₀FNO₃S

CAS No.

150322-43-3

SMILES

FC1=CC=CC=C1C(C(C2CC2)=O)N3CCC4=C(C3)C=C(S4)OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (267.78 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6778 mL 13.3890 mL 26.7781 mL
5 mM 0.5356 mL 2.6778 mL 5.3556 mL
10 mM 0.2678 mL 1.3389 mL 2.6778 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PrasugrelPCR 4099PCR4099PCR-4099P2Y ReceptoractivemetaboliteantiplateletADPplateletaggregationInhibitorinhibitorinhibit

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Product Name:
Prasugrel
Cat. No.:
HY-15284
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