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  2. P2Y Receptor
  3. Prasugrel hydrochloride

Prasugrel hydrochloride (Synonyms: PCR 4099 hydrochloride)

Cat. No.: HY-15284A Purity: 99.57%
Handling Instructions

Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and prodrug, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.

For research use only. We do not sell to patients.

Prasugrel hydrochloride Chemical Structure

Prasugrel hydrochloride Chemical Structure

CAS No. : 389574-19-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
500 mg USD 594 In-stock
Estimated Time of Arrival: December 31
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Description

Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and prodrug, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].

IC50 & Target

P2Y12 receptor[1]

In Vivo

In rat platelets, Prasugrel hydrochloride active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC50 value of 1.8 μM[2].
Prasugrel hydrochloride acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel hydrochloride is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

409.90

Formula

C₂₀H₂₁ClFNO₃S

CAS No.

389574-19-0

SMILES

FC1=CC=CC=C1C(C(C2CC2)=O)N3CCC4=C(C3)C=C(S4)OC(C)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (101.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4396 mL 12.1981 mL 24.3962 mL
5 mM 0.4879 mL 2.4396 mL 4.8792 mL
10 mM 0.2440 mL 1.2198 mL 2.4396 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PrasugrelPCR 4099PCR4099PCR-4099P2Y ReceptoractivemetaboliteantiplateletADPplateletaggregationInhibitorinhibitorinhibit

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Product Name:
Prasugrel hydrochloride
Cat. No.:
HY-15284A
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