1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

Imidaprilate (Synonyms: 6366A; Imidaprilat)

Cat. No.: HY-109592
Handling Instructions

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

For research use only. We do not sell to patients.

Imidaprilate Chemical Structure

Imidaprilate Chemical Structure

CAS No. : 89371-44-8

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

IC50 & Target

IC50: 2.6 nM (ACE)[1]

In Vitro

Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM[1].

In Vivo

Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6498 mL 13.2489 mL 26.4978 mL
5 mM 0.5300 mL 2.6498 mL 5.2996 mL
10 mM 0.2650 mL 1.3249 mL 2.6498 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

377.39

Formula

C₁₈H₂₃N₃O₆

CAS No.

89371-44-8

SMILES

O=C([[email protected]](CN1C)N(C([[email protected]@H](N[[email protected]](C(O)=O)CCC2=CC=CC=C2)C)=O)C1=O)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Imidaprilate
Cat. No.:
HY-109592
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Imidaprilate

Cat. No.: HY-109592