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Referencia número: HY-109592

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Imidaprilate

(Synonyms: 6366A; Imidaprilat)

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Based on 1 Customer Validation

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM, and is used in the research of hypertensive disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.0%
No. CAS: 89371-44-8
Fòrmula: C₁₈H₂₃N₃O₆
Peso molecular:377.39

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Imidaprilate Chemical Structure

No. CAS: 89371-44-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC50: 2.6 nM (ACE)^[1]

In Vitro

Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC₅₀ of 1.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 89371-44-8
Appearance Solid
Peso molecular 377.39
Fòrmula C₁₈H₂₃N₃O₆
Color White to off-white
SMILES

O=C([C@H](CN1C)N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)C1=O)O
Synonyms

6366A; Imidaprilat
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kubo M, et al. Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activi [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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Imidaprilate

Ramipril

Imidapril hydrochloride

Trandolapril

Imidapril

Fosinopril sodium

Lisinopril dihydrate

Ramipril (Standard)

Talfirastide

MLN-4760

Imidapril hydrochloride (Standard)

Trandolapril (Standard)

Enalapril maleate

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Bioz

Imidaprilate

Ramipril

Imidapril hydrochloride

Trandolapril

Imidapril

Fosinopril sodium

Lisinopril dihydrate

Ramipril (Standard)

Talfirastide

MLN-4760

Imidapril hydrochloride (Standard)

Trandolapril (Standard)

Enalapril maleate

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Imidaprilate Related Classifications

HY-109592 Related Classifications

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