2. Metabolic Enzyme/Protease
  3. Drug Metabolite Phosphatase
  4. 6-Hydroxybenzbromarone

6-Hydroxybenzbromarone 

Cat. No.: HY-135774 Purity: 99.86%
COA Handling Instructions

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.

For research use only. We do not sell to patients.

6-Hydroxybenzbromarone Chemical Structure

6-Hydroxybenzbromarone Chemical Structure

CAS No. : 152831-00-0

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Customer Review

Based on 1 publication(s) in Google Scholar

6-Hydroxybenzbromarone Related Antibodies

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  • Purity & Documentation

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Description

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1].

IC50 & Target

IC50: 21.5 μM (EYA3); metabolite[1]
In Vitro

6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation[1].
6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6-Hydroxybenzbromarone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HUVEC cells
Concentration: 7.5 μM
Incubation Time: 72 hours 
Result: Inhibited HUVEC cells proliferation.
Molecular Weight

440.08

Appearance

Solid

Formula

C17H12Br2O4
CAS No.
SMILES

O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC(O)=CC=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (227.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2723 mL 11.3616 mL 22.7231 mL
5 mM 0.4545 mL 2.2723 mL 4.5446 mL
10 mM 0.2272 mL 1.1362 mL 2.2723 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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6-Hydroxybenzbromarone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

6-Hydroxybenzbromarone152831-00-0Drug MetabolitePhosphataseMetabolitecellmigrationtubulogenesisanti-angiogenicbiotransformationInhibitorinhibitorinhibit

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