1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Desmethyl Erlotinib

Desmethyl Erlotinib (Synonyms: OSI-420; CP-473420)

Cat. No.: HY-13256 Purity: 98.90%
Handling Instructions

Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.

For research use only. We do not sell to patients.

Desmethyl Erlotinib Chemical Structure

Desmethyl Erlotinib Chemical Structure

CAS No. : 183320-51-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 642 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.

In Vivo

Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1].

Molecular Weight

415.87

Formula

C₂₁H₂₂ClN₃O₄

CAS No.

183320-51-6

SMILES

OCCOC1=CC2=C(N=CN=C2NC3=CC=CC(C#C)=C3)C=C1OCCOC.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4046 mL 12.0230 mL 24.0460 mL
5 mM 0.4809 mL 2.4046 mL 4.8092 mL
10 mM 0.2405 mL 1.2023 mL 2.4046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Desmethyl Erlotinib
Cat. No.:
HY-13256
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