1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Desmethyl Erlotinib hydrochloride

Desmethyl Erlotinib hydrochloride (Synonyms: OSI-420; CP-373420 hydrochloride)

Cat. No.: HY-13256 Purity: 98.69%
Handling Instructions

Desmethyl Erlotinib hydrochloride (OSI-420) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor.

For research use only. We do not sell to patients.

Desmethyl Erlotinib hydrochloride Chemical Structure

Desmethyl Erlotinib hydrochloride Chemical Structure

CAS No. : 183320-51-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 642 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Desmethyl Erlotinib hydrochloride:

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Description

Desmethyl Erlotinib hydrochloride (OSI-420) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1].

In Vivo

Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

415.87

Formula

C₂₁H₂₂ClN₃O₄

CAS No.

183320-51-6

SMILES

OCCOC1=CC2=C(N=CN=C2NC3=CC=CC(C#C)=C3)C=C1OCCOC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4046 mL 12.0230 mL 24.0460 mL
5 mM 0.4809 mL 2.4046 mL 4.8092 mL
10 mM 0.2405 mL 1.2023 mL 2.4046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

Desmethyl ErlotinibOSI-420CP-373420OSI420OSI 420CP373420CP 373420Drug MetaboliteInhibitorinhibitorinhibit

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Product Name:
Desmethyl Erlotinib hydrochloride
Cat. No.:
HY-13256
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