2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Drug Metabolite
  4. Flumazenil acid

Flumazenil acid  (Synonyms: Ro 15-3890)

Cat. No.: HY-118844 Purity: 99.97%
COA Handling Instructions

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Flumazenil acid is a metabolite of Flumazenil. Flumazenil is a GABAA receptor antagonist.

For research use only. We do not sell to patients.

Flumazenil acid Chemical Structure

Flumazenil acid Chemical Structure

CAS No. : 84378-44-9

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Based on 1 publication(s) in Google Scholar

Flumazenil acid Related Antibodies

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Description

Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].

Molecular Weight

275.24

Formula

C13H10FN3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)C1=C(N(C2=CC=C(C=C2C3=O)F)C=N1)CN3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (363.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6332 mL 18.1660 mL 36.3319 mL
5 mM 0.7266 mL 3.6332 mL 7.2664 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6332 mL 18.1660 mL 36.3319 mL 90.8298 mL
5 mM 0.7266 mL 3.6332 mL 7.2664 mL 18.1660 mL
10 mM 0.3633 mL 1.8166 mL 3.6332 mL 9.0830 mL
15 mM 0.2422 mL 1.2111 mL 2.4221 mL 6.0553 mL
20 mM 0.1817 mL 0.9083 mL 1.8166 mL 4.5415 mL
25 mM 0.1453 mL 0.7266 mL 1.4533 mL 3.6332 mL
30 mM 0.1211 mL 0.6055 mL 1.2111 mL 3.0277 mL
40 mM 0.0908 mL 0.4541 mL 0.9083 mL 2.2707 mL
50 mM 0.0727 mL 0.3633 mL 0.7266 mL 1.8166 mL
60 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.5138 mL
80 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1354 mL
100 mM 0.0363 mL 0.1817 mL 0.3633 mL 0.9083 mL
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Flumazenil acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flumazenil acid84378-44-9Ro 15-3890GABA ReceptorDrug MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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