2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. DL-Kynurenine

DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.

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DL-Kynurenine

DL-Kynurenine Chemical Structure

CAS No. : 343-65-7

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Description

DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity[1][2].

In Vivo

DL-Kynurenine (150-450 mg/kg, i.p., single dose) dose-dependently alleviates the motor behavior deficits caused by Quinolinic acid (HY-100807), and its combined use with Colchicine (HY-16569) can enhance this effect in rats[1].
DL-Kynurenine (0.1-40 μg/mice, 5 μL, i.c.v, single dose) significantly enhances the convulsive effect and mortality rate of Strychnine in mice[2].
DL-Kynurenine (25-100 mg/kg, i.p., single dose) prolongs the convulsive latency period of Strychnine, but does not alter the convulsive threshold[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Quinolinic acid induced dopamine system neurotoxicity model established by male Wistar rats (200-250 g)[1]
Dosage: 150, 300, and 450 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Dose-dependently alleviated the motor behavior deficits, and its combined use with colchicine can enhance this effect.
Dose-dependently prevented the toxic damage of Quinolinic acid to GABAergic neurons.
Animal Model: Seizure models induced by three types of convulsant agents Albino SHR mice of both sexes weighing 18-22 g[2]
Dosage: 0.1, 1, 4 and 40 μg/mice, 5 μL
Administration: Intraventricular injection (i.c.v.), single dose
Result: Selectively enhanced the convulsive and lethal effects of Strychnine.
Had no significant influence on convulsions caused by Pentylenetetrazol and Thiosemicarbazide (HY-Y0032).
Animal Model: Seizure models induced by three types of convulsant agents Albino SHR mice of both sexes weighing 18-22 g[2]
Dosage: 25, 50, 100 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Extended the latency period of convulsions caused by Strychnine and Thiosemicarbazide.
Molecular Weight

208.21

Formula

C10H12N2O3
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

NC1=CC=CC=C1C(CC(N)C(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 20 mg/mL (96.06 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.95%

SDS (252 KB)

COA (249 KB) HNMR (132 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M HCl 1 mM 4.8028 mL 24.0142 mL 48.0284 mL 120.0711 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL 24.0142 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL 12.0071 mL
15 mM 0.3202 mL 1.6009 mL 3.2019 mL 8.0047 mL
20 mM 0.2401 mL 1.2007 mL 2.4014 mL 6.0036 mL
25 mM 0.1921 mL 0.9606 mL 1.9211 mL 4.8028 mL
30 mM 0.1601 mL 0.8005 mL 1.6009 mL 4.0024 mL
40 mM 0.1201 mL 0.6004 mL 1.2007 mL 3.0018 mL
50 mM 0.0961 mL 0.4803 mL 0.9606 mL 2.4014 mL
60 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0012 mL
80 mM 0.0600 mL 0.3002 mL 0.6004 mL 1.5009 mL
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DL-Kynurenine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Kynurenine343-65-7Endogenous Metabolitenolinic acidkynurenic acidkynurenineprobenecidexcitotoxicityNMDA receptorGABAcircling behaviorInhibitorinhibitorinhibit

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