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L-Kynurenine

30 Cited Publications
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Based on 30 publication(s) in Google Scholar

L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

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  • Purity: 99.93%
  • CAS No.: 2922-83-0
  • Formula: C10H12N2O3
  • Molecular Weight:208.21
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • L-Kynurenine Chemical Structure
    L-Kynurenine Chemical Structure
  • Experimental Validation Results for L-Kynurenine
  • Experimental Validation Results for L-Kynurenine
  • Experimental Validation Results for L-Kynurenine
  • Experimental Validation Results for L-Kynurenine
  • Experimental Validation Results for L-Kynurenine
CAS No.: 2922-83-0
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  • L-Kynurenine Chemical Structure
    L-Kynurenine Chemical Structure
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    L-Kynurenine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Nov 13;32(11):1927-1943.e9. [Abstract]

    Customer Validation
     After antibiotic treatment, Ahrflox/floxAdipoq-Cre mice and Ahrflox/flox mice are gavaged with L-kynurenine (5 mg/mL; p.o.; three times a week for 8 weeks), A. pulmonis (109 CFU/mouse/dose) or PBS control three times a week for 8 weeks. Meanwhile, mice are challenged by four cycles of 1.5% DSS.

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    L-Kynurenine purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2024 Oct 24;29(1):26. [Abstract]

    Customer Validation
     Immunofluorescence staining shows increased nuclear staining of AHR after cells are treated with 20 µM Kyn (20 µM; 30 min) compared with control cells. The re-localization of AHR (green) or PD-L1 (green) in SKOV3 cells treated with 20 µM Kyn for 30 min. Nuclei are counterstained with DAPI (blue).

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    L-Kynurenine purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 Mar 1;42(1):52. [Abstract]

    Customer Validation
     L-kynurenine (0-200 μM; 24-48 h). The proportion of FVD+ NK-92 cells when treated with gradient concentrations of L-KYN (L-kynurenine) for 24 or 48 h.

  • 1/16

    L-Kynurenine purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2023 Oct 11.

    Customer Validation
     L-Kynurenine (2 mg/mL; feeding water; from the 7th to 13th day of pregnancy). Kyn is used to treat infected IDO–/– pregnant mice. The adverse pregnancy outcomes of IDO –/– infected mice after treatment with exogenous Kyn are significantly improved. Mental status, uterus, developmental status of placentas and fetuses in the infected, IDO –/– infected and IDO –/– infected with Kyn treated groups.

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    L-Kynurenine purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2020 Jul 17;16(7):e1008664. [Abstract]

    Customer Validation
     MT-1 cells are treated with Kynurenine (10, 50 μM) for 48 h or 4 days , then subjected to analyze the level of cytosolic AHR and nuclear AHR by immunoblot. After 4-days treatment, Kynurenine (10, 50 μM) remarkably induces the expression of CYP1A1 and plus-strand genes in a dose-dependent manner. Both groups efficiently triggered the production of Tax protein, p19 and p24, although the accumulation of gp46 is no apparent.

  • L-Kynurenine