L-Kynurenine-d4
Based on 1 publication(s) in Google Scholar
L-Kynurenine-d4 is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.80%
- CAS 番号: 2672568-86-2
- 分子式: C10H8D4N2O3
- 分子量:212.24
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-104026
L-KynurenineAryl Hydrocarbon Receptor Agonist -
HY-104026R
L-Kynurenine (Standard)Aryl Hydrocarbon Receptor Agonist -
HY-N0623S
L-Tryptophan-d5Stable Isotope -
HY-100806S
Kynurenic acid-d5Stable Isotope -
HY-100807S
Quinolinic acid-d3Stable Isotope -
HY-N0623S9
L-Tryptophan-d3Stable Isotope -
HY-N0623S5
L-Tryptophan-d8Stable Isotope -
HY-W013812
Ethyl linoleateAntiinflammatory Agent -
HY-N0623R
L-Tryptophan (standard)Essential Amino Acid -
HY-100806R
Kynurenic acid (Standard)iGluR/α7 nAChR Antagonist -
HY-100806
Kynurenic acidiGluR/α7 nAChR Antagonist -
HY-100807
Quinolinic acidNMDA Receptor Agonist
MedChemExpress（MCE）の使用を引用している文献 L-Kynurenine-d4
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 2672568-86-2
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非標識Cas 2922-83-0
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性状 Solid
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分子量 212.24
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分子式 C10H8D4N2O3
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Color White to light yellow
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SMILES
O=C([C@H](C([2H])([2H])C(C1=CC([2H])=CC([2H])=C1N)=O)N)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Redox Biol
Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice. [Abstract]2026 Feb:89:103957. PMID: 41389767
溶剤 & 溶解度
体外:
DMSO : 2.5 mg/mL (11.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. [Content Brief]
[3]. Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7. [Content Brief]
[4]. Nozaki K, et al. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab. 1992 May;12(3):400-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7116 mL | 23.5581 mL | 47.1163 mL | 117.7906 mL |
| 5 mM | 0.9423 mL | 4.7116 mL | 9.4233 mL | 23.5581 mL | |
| 10 mM | 0.4712 mL | 2.3558 mL | 4.7116 mL | 11.7791 mL |
L-Kynurenine-d4 関連分類
HY-104026S 関連分類
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