2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite Aryl Hydrocarbon Receptor
  4. L-Kynurenine sulfate

L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype.

For research use only. We do not sell to patients.

L-Kynurenine sulfate Chemical Structure

L-Kynurenine sulfate Chemical Structure

CAS No. : 16055-80-4

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L-Kynurenine sulfate Related Antibodies

Top Publications Citing Use of Products

    L-Kynurenine sulfate purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2020 Jul 17;16(7):e1008664.  [Abstract]

    MT-1 cells are treated with Kynurenine (10, 50 μM) for 48 h or 4 days , then subjected to analyze the level of cytosolic AHR and nuclear AHR by immunoblot. After 4-days treatment, Kynurenine (10, 50 μM) remarkably induces the expression of CYP1A1 and plus-strand genes in a dose-dependent manner. Both groups efficiently triggered the production of Tax protein, p19 and p24, although the accumulation of gp46 is no apparent.

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    Description

    L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    Molecular Weight

    306.29

    Formula

    C10H14N2O7S
    CAS No.
    SMILES

    O=S(O)(O)=O.O=C(O)[C@@H](N)CC(C1=CC=CC=C1N)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    L-Kynurenine sulfate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Kynurenine16055-80-4Endogenous MetaboliteAryl Hydrocarbon ReceptorAhRObesityLiver steatosisInhibitorinhibitorinhibit

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