1. Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Endogenous Metabolite
    Aryl Hydrocarbon Receptor
  3. Indole-3-pyruvic acid

Indole-3-pyruvic acid 

Cat. No.: HY-W028393 Purity: 95.44%
Handling Instructions

Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.

For research use only. We do not sell to patients.

Indole-3-pyruvic acid Chemical Structure

Indole-3-pyruvic acid Chemical Structure

CAS No. : 392-12-1

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50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety[1][2][3].

IC50 & Target

Microbial Metabolite

 

In Vitro

Indole-3-pyruvic acid (50 and 250 μM, 24 h) activates AHR in HepG2 cells[1].
Indole-3-pyruvic acid (50 μM, 4 days) does not inhibit Th1 cell differentiation but promotes Tr1 differentiation[1].
Indole-3-pyruvic acid (1 mM, 24 h) reduces UVB-induced cytotoxicity in HaCaT cells[1].
Indole-3-pyruvic acid (25 mM, 6 h) reduces the levels of COX-2 in HaCaT cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: HaCaT cells
Concentration: 5-25 mM
Incubation Time: 6 h
Result: Inhibited UVB-stimulated mRNA expression of IL-1β, IL-6, and cyclooxygenase 2 (Cox-2).
In Vivo

Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 d) activates AHR in BALB/c mice[1].
Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 wk) abrogates chronic inflammation in a T cell-mediated colitis model[1].
Indole-3-pyruvic acid (100 μM, dose at skin) protects against UVB-induced skin damage in HR-1 hairless mice[2].
Indole-3-pyruvic acid (intraperitoneal injection, 100-200 mg/kg) increases the time spent in the open arms of the elevated plus maze in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: Fed in MF chow.0.1% for 5 d
Administration: Oral administration
Result: Up-regulated the expression of Cyp1a1 (a biomarker for AHR activation) in the colon.
Animal Model: T cell–mediated colitis model of SCID mice[1]
Dosage: Fed in MF chow.0.1% for 5 wk
Administration: Oral administration
Result: Suppressed diarrhea and improved colon inflammation.
Down-regulated the expression of Th1 and proinflammatory cytokines and upregulated the expression of IL-10 in the colon.
Animal Model: HR-1 Hairless Mice[2]
Dosage: 100 μM
Administration: Dose at skin
Result: Enhanced the epidermal thickness.
Attenuated UVB-induced necrosis observed in upper layer of dermis.
Molecular Weight

203.19

Formula

C11H9NO3

CAS No.
SMILES

O=C(O)C(CC1=CNC2=CC=CC=C12)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1230.38 mM; Need ultrasonic)

H2O : 20 mg/mL (98.43 mM; ultrasonic and adjust pH to 12 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9215 mL 24.6075 mL 49.2150 mL
5 mM 0.9843 mL 4.9215 mL 9.8430 mL
10 mM 0.4922 mL 2.4608 mL 4.9215 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.24 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Indole-3-pyruvic acid
Cat. No.:
HY-W028393
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