BAY 2416964
Based on 1 publication(s) in Google Scholar
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.59%
- No. CAS: 2242464-44-2
- Fòrmula: C18H18ClN5O3
- Peso molecular:387.82
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) BAY 2416964
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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RT-PCR
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Actividad biológica
IC50: 341 nM (Aryl hydrocarbon receptor (AHR))[1]
BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2242464-44-2
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Appearance Solid
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Peso molecular 387.82
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Fòrmula C18H18ClN5O3
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Color Light yellow to green yellow
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SMILES
O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CN(C)N=C3)C1=O)N[C@@H](C)CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Oncol (Dordr)
PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling. [Abstract]2025 Dec 23;49(1):3. PMID: 41432900
BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3. [Abstract]
IC50 of Py8119 or Py230 cells treated with 10 nM FICZ, 1 µM 5F-203, 1 µM tapinarof, or 1 µM BAY2416964 in combination with 0.01 to 1000 nM RBN2397, n = 8. RBN2397 treatment alone from Fig. 4C is added for comparison.
BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3. [Abstract]
IC50 curve of Py230 and Py8119 cells treated with fixed concentration of 10 µg/mL DMXAA and 1 µM BAY2416964 with 0.01 to 1000 nM RBN2397.
BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3. [Abstract]
Fosl1 mRNA levels in Py230 cells treated for 48 h with DMSO, 10 µg/ml DMXAA, 100 nM RBN2397 and 1 µM BAY2416964 alone or in combination or DMSO treated Py8119 cells.
BAY 2416964 purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2025 Dec 23;49(1):3. [Abstract]
Western blot of Py230 cells treated DMSO, 10 µg/ml DMXAA, 100 nM RBN2397 and 1 µM BAY2416964 alone or in combination for 72 h. 30 µg protein loaded. Representative image of n = 2.
Solvente y solubilidad
DMSO : 50 mg/mL (128.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.45 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Italian - IT (393 KB)
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- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5785 mL | 12.8926 mL | 25.7852 mL | 64.4629 mL |
| 5 mM | 0.5157 mL | 2.5785 mL | 5.1570 mL | 12.8926 mL | |
| 10 mM | 0.2579 mL | 1.2893 mL | 2.5785 mL | 6.4463 mL | |
| 15 mM | 0.1719 mL | 0.8595 mL | 1.7190 mL | 4.2975 mL | |
| 20 mM | 0.1289 mL | 0.6446 mL | 1.2893 mL | 3.2231 mL | |
| 25 mM | 0.1031 mL | 0.5157 mL | 1.0314 mL | 2.5785 mL | |
| 30 mM | 0.0860 mL | 0.4298 mL | 0.8595 mL | 2.1488 mL | |
| 40 mM | 0.0645 mL | 0.3223 mL | 0.6446 mL | 1.6116 mL | |
| 50 mM | 0.0516 mL | 0.2579 mL | 0.5157 mL | 1.2893 mL | |
| 60 mM | 0.0430 mL | 0.2149 mL | 0.4298 mL | 1.0744 mL | |
| 80 mM | 0.0322 mL | 0.1612 mL | 0.3223 mL | 0.8058 mL | |
| 100 mM | 0.0258 mL | 0.1289 mL | 0.2579 mL | 0.6446 mL |
BAY 2416964 Related Classifications
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