1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. AHR antagonist 3

AHR antagonist 3 

Cat. No.: HY-135829
Handling Instructions

AHR antagonist 3 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. AHR antagonist 3 has anti-cancer effects.

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AHR antagonist 3 Chemical Structure

AHR antagonist 3 Chemical Structure

CAS No. : 2242464-44-2

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Description

AHR antagonist 3 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. AHR antagonist 3 has anti-cancer effects[1].

IC50 & Target

IC50: 341 nM (Aryl hydrocarbon receptor (AHR))[1]

In Vitro

AHR antagonist 3 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM[1].

Molecular Weight

387.82

Formula

C₁₈H₁₈ClN₅O₃

CAS No.

2242464-44-2

SMILES

O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CN(C)N=C3)C1=O)N[[email protected]@H](C)CO

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AHR antagonist 3AHR antagonist3AHR antagonist-3Aryl Hydrocarbon ReceptorAhR2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamideAHRanti-cancerCYP1A1Inhibitorinhibitorinhibit

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AHR antagonist 3
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