1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. GNF351

GNF351 

Cat. No.: HY-102023 Purity: 99.90%
Handling Instructions

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes.

For research use only. We do not sell to patients.

GNF351 Chemical Structure

GNF351 Chemical Structure

CAS No. : 1227634-69-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1].

IC50 & Target

IC50: 62 nM (aryl hydrocarbon receptor)[1]

In Vitro

GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1].

Cell Proliferation Assay[1]

Cell Line: Human primary keratinocytes
Concentration: 500 nM
Incubation Time: 48 hours
Result: Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.
Molecular Weight

411.50

Formula

C₂₄H₂₅N₇

CAS No.

1227634-69-6

SMILES

CC1=CN=CC(C2=NC(NCCC3=CNC4=C3C=CC=C4)=C5N=CN(C(C)C)C5=N2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (303.77 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4301 mL 12.1507 mL 24.3013 mL
5 mM 0.4860 mL 2.4301 mL 4.8603 mL
10 mM 0.2430 mL 1.2151 mL 2.4301 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
GNF351
Cat. No.:
HY-102023
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