343-65-7
Chemical Structure
DL-Kynurenine
- CAS 番号: 343-65-7
- Formula:C10H12N2O3
- Molecular Weight:208.21
IUPAC Name: 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid
InChIKey: YGPSJZOEDVAXAB-UHFFFAOYSA-N
SMILES: NC1=CC=CC=C1C(CC(N)C(O)=O)=O
Biological Activity: DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity[1][2].
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DL-Kynurenine | 98.95% | DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity. | ||||||||||||||||||||
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DL-Kynurenine (Standard) | 98.52% | DL-Kynurenine (Standard) is the analytical standard of DL-Kynurenine. This product is intended for research and analytical applications. DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity. | ||||||||||||||||||||
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References
- [1]. Santamaría A, et al. Systemic DL-kynurenine and probenecid pretreatment attenuates quinolinic acid-induced neurotoxicity in rats. Neuropharmacology. 1996 Jan;35(1):23-8. [Content Brief]
- [2]. Lapin IP. Effect of kynurenine and quinolinic acid on the action of convulsants in mice. Pharmacol Biochem Behav. 1980 Jul;13(1):17-20. [Content Brief]
