trans-trans-Muconic acid-d4
Based on 1 Customer Validation
trans-trans-Muconic acid-d4 is the deuterium labeled trans-trans-Muconic acid. trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 1955496-83-9
- Formula: C6H2D4O4
- Molecular Weight:146.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1955496-83-9
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Unlabeled Cas 3588-17-8
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Appearance Solid
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Molecular Weight 146.13
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Formula C6H2D4O4
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Color White to off-white
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SMILES
OC(/C([2H])=C([2H])/C([2H])=C([2H])/C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 50 mg/mL (342.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Bartczak A, ET AL. Evaluation of assays for the identification and quantitation of muconic acid, a benzene metabolite in human urine. J Toxicol Environ Health. 1994 Jul;42(3):245-58. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.8432 mL | 34.2161 mL | 68.4322 mL | 171.0805 mL |
| 5 mM | 1.3686 mL | 6.8432 mL | 13.6864 mL | 34.2161 mL | |
| 10 mM | 0.6843 mL | 3.4216 mL | 6.8432 mL | 17.1081 mL | |
| 15 mM | 0.4562 mL | 2.2811 mL | 4.5621 mL | 11.4054 mL | |
| 20 mM | 0.3422 mL | 1.7108 mL | 3.4216 mL | 8.5540 mL | |
| 25 mM | 0.2737 mL | 1.3686 mL | 2.7373 mL | 6.8432 mL | |
| 30 mM | 0.2281 mL | 1.1405 mL | 2.2811 mL | 5.7027 mL | |
| 40 mM | 0.1711 mL | 0.8554 mL | 1.7108 mL | 4.2770 mL | |
| 50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4216 mL | |
| 60 mM | 0.1141 mL | 0.5703 mL | 1.1405 mL | 2.8513 mL | |
| 80 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1385 mL | |
| 100 mM | 0.0684 mL | 0.3422 mL | 0.6843 mL | 1.7108 mL |
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