2. Apoptosis Epigenetics Cell Cycle/DNA Damage MAPK/ERK Pathway Stem Cell/Wnt Anti-infection
  3. Apoptosis Caspase PARP ERK MDM-2/p53 JNK HSV
  4. Prostaglandin A2

Prostaglandin A2  (Synonyms: PGA2; Medullin)

Cat. No.: HY-113041 Purity: 99.9%
COA
SDS
Handling Instructions Technical Support

Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis.

For research use only. We do not sell to patients.

Prostaglandin A2

Prostaglandin A2 Chemical Structure

CAS No. : 13345-50-1

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Solvent
1 mg (29.90 mM * 100 μL in Methyl acetate) In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of Prostaglandin A2:

Prostaglandin A2 Related Antibodies

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Description

Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis[1][2][3].

IC50 & Target[2][1][3]

JNK1

 

ERK2

 

PARP-1

 

Caspase 3

 

HSV-1

 

In Vitro

Prostaglandin A2 (5-15 μg/mL; 12 h) induces caspase-dependent apoptosis in HCT116 (wild-type p53) cells, but exerts no such effect in HCT116 p53-/- cells[1].
Prostaglandin A2 (36 μM; 48 h) induces growth arrest in MCF-7 human breast cancer cells, and triggers apoptotic death in RKOneo and RKOE6 human colorectal cancer cells[2].
Prostaglandin A2 (36 μM; 30-120 min) potently activates ERK2 and JNK1/SAPK kinases in MCF-7 cells, but exerts no such effect in RKO cells[2].
Prostaglandin A2 inhibits the replication of HSV-1 strain McKrae in rabbit stromal cells, with an ED50 of 1.2 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prostaglandin A2 Related Antibodies

Western Blot Analysis[1]

Cell Line: human colorectal HCT116 (wild-type p53) cells, HCT116 p53-/- cells
Concentration: 5, 10, 15 μg/mL
Incubation Time: 12 h
Result: Induced cleavage of PARP1 and caspase-3 in HCT116 cells in a dose-dependent manner, but not in HCT116 p53-/- cells.
Increased p53 protein levels and p53 phosphorylation at Ser-15 in HCT116 cells in a dose-dependent manner.
In Vivo

Prostaglandin A2 (0.5-2.0 mg/mL; topical; treatment initiates on day 3 post-infection and continues through day 7 post-infection) shows no significant beneficial effect on HSV-1-induced herpetic keratitis in rabbits[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbits (2.3 to 2.7 kg, free of preexisting corneal defects)[3]
Dosage: 0.5 mg/mL; 1.0 mg/mL; 2.0 mg/mL
Administration: topical eyedrops; five doses per day every 2 hours; days 3 to 7 post-infection
Result: Showed only one significant epithelial lesion score reduction vs.
placebo at a single dose and time point; overall, epithelial disease did not respond in a dose-dependent manner.
Recorded mean lesion scores on day 8 post-infection of 1.7 (1 mg/mL) and 2.1 (2 mg/mL).
Observed no significant differences in corneal thickness between treated and placebo groups at peak stromal involvement (12 to 14 days post-infection), with mean corneal thicknesses at day 12 post-infection of 473 ± 23 μm (0.5 mg/mL), 582 ± 76 μm (1.0 mg/mL), and 541 ± 42 μm (2.0 mg/mL).
Detected significantly higher anterior chamber flare scores in treated groups vs.
placebo in a dose-dependent manner, with mean flare scores after 1 day of therapy of 0.44 (0.5 mg/mL), 0.88 (1 mg/mL), and 1.03 (2 mg/mL).
Caused worse long-term sequelae in treated rabbits, with mean corneal thickness at 67 days post-infection of 569 ± 120 μm (1 mg/mL) and 694 ± 124 μm (2 mg/mL) vs.
480 ± 70 μm for placebo, and 14 of 28 treated eyes developing necrotizing stromal keratitis vs.
3 of 10 placebo eyes.
Observed no differences in virus recovery from trigeminal ganglia or corneas between treated and placebo groups, with 15 of 18 trigeminal ganglia from treated rabbits yielding infectious virus upon cocultivation, and 4 of 18 or 5 of 12 corneas from treated rabbits yielding infectious virus.
Molecular Weight

334.45

Formula

C20H30O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)C/C=C\CCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, protect from light, 2 years
Purity & Documentation

Purity: 99.9%

SDS (558 KB)

COA (253 KB) RP-HPLC (119 KB) MS (165 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)
References
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Prostaglandin A2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prostaglandin A213345-50-1PGA2 MedullinProstaglandin A 2Prostaglandin A-2PGA 2PGA-2ApoptosisCaspasePARPERKMDM-2/p53JNKHSVpoly ADP ribose polymerase Extracellular signal regulated kinasesc-Jun N-terminal kinaseHerpes simplex virusp53cyclin-dependent kinasesDNA-activated protein kinasepoly(ADP-ribose) polymerase 1histone H2AXDR5extracellular signal-regulated kinasec-Jun terminal kinase 1/stress-activated protein kinasecaspase-3colorectal cancerInhibitorinhibitorinhibit

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