13345-50-1
Chemical Structure
Prostaglandin A2
Synonym(s): PGA2; Medullin
- CAS No.: 13345-50-1
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (Z)-7-((1R,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)hept-5-enoic acid
InChIKey: MYHXHCUNDDAEOZ-FOSBLDSVSA-N
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)C/C=C\CCCC(O)=O
Biological Activity: Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prostaglandin A2 | 99.9% | Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis. | ||||||||||||||||||||
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Prostaglandin A2-d4 | Prostaglandin A2-d4 is the deuterium labeled Prostaglandin A2. | |||||||||||||||||||||
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- [1]. Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020;10(3):492. Published 2020 Mar 24. [Content Brief]
- [2]. Gorospe M, et al. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16(12):6654-60. [Content Brief]
- [3]. O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996;40(10):2327-2331. [Content Brief]
Keywords
