13345-50-1
Chemical Structure
Prostaglandin A2
Synonym(s): PGA2; Medullin
- CAS No.: 13345-50-1
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (Z)-7-((1R,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)hept-5-enoic acid
InChIKey: MYHXHCUNDDAEOZ-FOSBLDSVSA-N
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)C/C=C\CCCC(O)=O
Biological Activity:
Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis[1][2][3].
The product specifications provided below refer solely to the active content of Prostaglandin A2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prostaglandin A2 | 99.9% | Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis. The product specifications provided below refer solely to the active content of Prostaglandin A2. |
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Prostaglandin A2-d4 | Prostaglandin A2-d4 is the deuterium labeled Prostaglandin A2. | |||||||||||||||||||||
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Similarity Score 1.00
HY-11489215-A2t-Isoprostane -
Similarity Score 0.89
HY-118728Prostaglandin A2 methyl ester -
Similarity Score 0.89
HY-113366Prostaglandin J2 -
Similarity Score 0.88
HY-16507619(R)-Hydroxy prostaglandin A2 -
Similarity Score 0.87
HY-114822Prostaglandin A3 -
Similarity Score 0.86
HY-113053Prostaglandin A1 -
Similarity Score 0.86
HY-1145998-iso Prostaglandin A1 -
Similarity Score 0.86
HY-11496115-epi Prostaglandin A1 -
Similarity Score 0.84
HY-11491011-Deoxy Prostaglandin E2 -
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References
- [1]. Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020;10(3):492. Published 2020 Mar 24. [Content Brief]
- [2]. Gorospe M, et al. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16(12):6654-60. [Content Brief]
- [3]. O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996;40(10):2327-2331. [Content Brief]
