15-A2t-Isoprostane
15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid.
For research use only. We do not sell to patients.
- CAS No.: 474391-66-7
- Formula: C20H30O4
- Molecular Weight:334.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
15-A2t-Isoprostane (10, 30 μM, 3 h) enhances glutamate-induced cytotoxicity and decreases glutathione (GSH) levels in HT22 hippocampus cells[2].
15-A2t-Isoprostane (10 μM, 24 h) inhibits VEGF induced human coronary endothelial cell migration and tubule formation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 474391-66-7
-
Molecular Weight 334.45
-
Formula C20H30O4
-
SMILES
O=C1[C@H]([C@H](C=C1)/C=C/[C@H](CCCCC)O)C/C=C\CCCC(O)=O
-
Synonyms
8-iso Prostaglandin A2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274(16):10863-8. [Content Brief]
[2]. Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97(5):1301-13. [Content Brief]
[3]. Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103(9):1037-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
15-A2t-Isoprostane Related Classifications
HY-114892 Related Classifications
Powered by Bioz