474391-66-7
474391-66-7
Chemical Structure
15-A2t-Isoprostane
Synonym(s): 8-iso Prostaglandin A2
- CAS No.: 474391-66-7
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (Z)-7-((1S,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)hept-5-enoic acid
InChIKey: MYHXHCUNDDAEOZ-UKUWKSPLSA-N
SMILES: O=C1[C@H]([C@H](C=C1)/C=C/[C@H](CCCCC)O)C/C=C\CCCC(O)=O
Biological Activity: 15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid[1][2][3].
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15-A2t-Isoprostane | 15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid. | |||||||||||||||||||||
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References
- [1]. Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274(16):10863-8. [Content Brief]
- [2]. Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97(5):1301-13. [Content Brief]
- [3]. Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103(9):1037-46. [Content Brief]
Keywords
