11-Deoxy Prostaglandin E2
Based on 1 Customer Validation
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.0%
- CAS No.: 35536-53-9
- 화학식: C20H32O4
- 분자량:336.47
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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HY-113042
Prostaglandin B2Prostaglandin -
HY-137584
1a,1b-Dihomo prostaglandin E1E1-Type Prostaglandin -
HY-126986
Tetranor-PGDMPGD2 Metabolite -
HY-118548
Tetranor-PGAMTetranor-Prostaglandin A Metabolite -
HY-117659
PGDMUrinary Metabolite -
HY-163373
13,14-Dihydro-15-keto prostaglandin D1Derivative of Prostaglandin D1 -
HY-124219
17-Phenoxy trinor prostaglandin F2α ethyl amideFP Receptor Agonist -
HY-168802
9-Keto tafluprostTafluprost Derivative
Biological Activity
제품 설명
Chemical Information
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CAS No. 35536-53-9
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Appearance Solid
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분자량 336.47
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화학식 C20H32O4
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Color White to off-white
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SMILES
CCCCC[C@@H](/C=C/[C@@H](CCC1=O)[C@H]1C/C=C\CCCC(O)=O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (297.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
순도&문서
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Data Sheet (284 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37. [Content Brief]
[2]. Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9720 mL | 14.8602 mL | 29.7203 mL | 74.3008 mL |
| 5 mM | 0.5944 mL | 2.9720 mL | 5.9441 mL | 14.8602 mL | |
| 10 mM | 0.2972 mL | 1.4860 mL | 2.9720 mL | 7.4301 mL | |
| 15 mM | 0.1981 mL | 0.9907 mL | 1.9814 mL | 4.9534 mL | |
| 20 mM | 0.1486 mL | 0.7430 mL | 1.4860 mL | 3.7150 mL | |
| 25 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9720 mL | |
| 30 mM | 0.0991 mL | 0.4953 mL | 0.9907 mL | 2.4767 mL | |
| 40 mM | 0.0743 mL | 0.3715 mL | 0.7430 mL | 1.8575 mL | |
| 50 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL | |
| 60 mM | 0.0495 mL | 0.2477 mL | 0.4953 mL | 1.2383 mL | |
| 80 mM | 0.0372 mL | 0.1858 mL | 0.3715 mL | 0.9288 mL | |
| 100 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7430 mL |
11-Deoxy Prostaglandin E2 Related Classifications
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