Prostaglandin J2 (Synonyms: PGJ2)

Cat. No.: HY-113366: FAQs
Data Sheet SDS Handling Instructions

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Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD).

For research use only. We do not sell to patients.

Prostaglandin J2 Chemical Structure

CAS No. : 60203-57-8

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500 μg	USD 202	Ask For Quote & Lead Time

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Other Forms of Prostaglandin J2:

Prostaglandin J2-d₄ Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]^[2]

hDP

0.9 nM (Ki)

hCRTH2

6.6 nM (Ki)

hEP1

15.678 μM (Ki)

hEP2

989 nM (Ki)

hEP3

319 nM (Ki)

hEP4

1065 nM (Ki)

hFP

553 nM (Ki)

hIP

>25 μM (Ki)

hTP

6426 nM (Ki)

Human Endogenous Metabolite

In Vivo

Prostaglandin J2 (PGJ2; 33.4 μg/injection; unilateral injection to the SNpc; once per week for 2 or 4 weeks) induces progressive PD-like pathology and exhibites microglia and astrocyte activation and motor deficits in the rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sixteen-week-old Sprague Dawley male rats^[4]
Dosage:	33.4 μg/injection
Administration:	Unilateral (right side) injections to the SNpc; once per week for 2 or 4 weeks
Result:	Induced progressive dopaminergic neuronal loss in the rat substantia nigra pars compacta (SNpc). Developed parkinsonian-like motor deficits in a progressive manner.

Molecular Weight

334.45

Formula

C₂₀H₃₀O₄

CAS No.

60203-57-8

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\CCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (149.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9900 mL	14.9499 mL	29.8998 mL
5 mM	0.5980 mL	2.9900 mL	5.9800 mL
10 mM	0.2990 mL	1.4950 mL	2.9900 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (278 KB) SDS (394 KB) Handling Instructions (2659 KB)

References

[1]. D H Wright, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. [Content Brief]

[2]. Nicole Sawyer, et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. [Content Brief]

[3]. Maria E Figueiredo-Pereira, et al. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Ann N Y Acad Sci. 2016 Jan;1363(1):125-37. [Content Brief]

[4]. Chuhyon Corwin, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018 Sep 20;15(1):272. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9900 mL	14.9499 mL	29.8998 mL	74.7496 mL
	5 mM	0.5980 mL	2.9900 mL	5.9800 mL	14.9499 mL
	10 mM	0.2990 mL	1.4950 mL	2.9900 mL	7.4750 mL
	15 mM	0.1993 mL	0.9967 mL	1.9933 mL	4.9833 mL
	20 mM	0.1495 mL	0.7475 mL	1.4950 mL	3.7375 mL
	25 mM	0.1196 mL	0.5980 mL	1.1960 mL	2.9900 mL
	30 mM	0.0997 mL	0.4983 mL	0.9967 mL	2.4917 mL
	40 mM	0.0747 mL	0.3737 mL	0.7475 mL	1.8687 mL
	50 mM	0.0598 mL	0.2990 mL	0.5980 mL	1.4950 mL
	60 mM	0.0498 mL	0.2492 mL	0.4983 mL	1.2458 mL
	80 mM	0.0374 mL	0.1869 mL	0.3737 mL	0.9344 mL
	100 mM	0.0299 mL	0.1495 mL	0.2990 mL	0.7475 mL

Prostaglandin J2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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