60203-57-8
Chemical Structure
Prostaglandin J2
Synonym(s): PGJ2
- CAS No.: 60203-57-8
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (Z)-7-((1S,5R)-5-((S,E)-3-hydroxyoct-1-en-1-yl)-4-oxocyclopent-2-en-1-yl)hept-5-enoic acid
InChIKey: UQOQENZZLBSFKO-POPPZSFYSA-N
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\CCCC(O)=O
Biological Activity:
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD)[1][2][3][4].
The product specifications provided below refer solely to the active content of Prostaglandin J2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prostaglandin J2 | 98.1% | Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD). The product specifications provided below refer solely to the active content of Prostaglandin J2. |
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Prostaglandin J2-d4 | Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2. | |||||||||||||||||||||
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Similarity Score 0.89
HY-113041Prostaglandin A2 -
Similarity Score 0.89
HY-11489215-A2t-Isoprostane -
Similarity Score 0.82
HY-11491011-Deoxy Prostaglandin E2 -
Similarity Score 0.79
HY-113053Prostaglandin A1 -
Similarity Score 0.79
HY-1145998-iso Prostaglandin A1 -
Similarity Score 0.79
HY-11496115-epi Prostaglandin A1 -
Similarity Score 0.79
HY-N1548313,14-Dihydro-15-keto prostaglandin J2 -
Similarity Score 0.79
HY-180645Prostaglandin C2 -
Similarity Score 0.78
HY-114822Prostaglandin A3 -
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References
- [1]. D H Wright, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. [Content Brief]
- [2]. Nicole Sawyer, et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. [Content Brief]
- [3]. Maria E Figueiredo-Pereira, et al. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Ann N Y Acad Sci. 2016 Jan;1363(1):125-37. [Content Brief]
- [4]. Chuhyon Corwin, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018 Sep 20;15(1):272. [Content Brief]
