Octacosane
Based on 1 Customer Validation
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l.
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- Pureté : 98.0%
- CAS No.: 630-02-4
- Formule: C28H58
- Masse moléculaire:394.76
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
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Human Endogenous Metabolite |
In Vitro
Octacosane (12.5-100 μg/ml; 18 h) displays strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10-Nex2 cells
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Concentration:12.5, 25, 50, 100 μg/ml
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Incubation Time:18 h
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Result:Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice with B16F10-Nex2 Cellsl[1]
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Dosage:500 μg
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Administration:Injected at peripheral sites in relation to the original cell grafting; daily; 35 days
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Result:Resulted in a significant delay of tumor progression with a significant antitumor effect.
The survival rate of treated groups was significantly increased.
Chemical Information
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CAS No. 630-02-4
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Appearance Solid
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Masse moléculaire 394.76
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Formule C28H58
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
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Synonyms
n-Octacosane; NSC 5549
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
Ethanol : < 1 mg/mL (insoluble)
Pureté et documentation
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Fiche technique (265 KB)
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SDS (562 KB)
- English - EN (562 KB)
- Français - FR (562 KB)
- Deutsch - DE (562 KB)
- Norwegian - NO (562 KB)
- Español - ES (562 KB)
- Swedish - SV (562 KB)
- Italian - IT (562 KB)
- Korean - KR (562 KB)
- Portuguese - PT (562 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. [Content Brief]
[2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [Content Brief]
[3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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