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Pseurotin A 

Cat. No.: HY-125916
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Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity.

For research use only. We do not sell to patients.

Pseurotin A Chemical Structure

Pseurotin A Chemical Structure

CAS No. : 58523-30-1

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Description

Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity[1][2][3].

In Vitro

Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner[3].
Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: BT-474 cells, T47D cells
Concentration: 40-200 μM
Incubation Time: 24-72 hours
Result: Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively).
In Vivo

Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)[1]
Dosage: 10 mg/kg
Administration: P.o.; 7X/week, 30 days
Result: Significantly suppressed the growth of BT474 tumors.
Molecular Weight

431.44

Formula

C₂₂H₂₅NO₈

CAS No.

58523-30-1

SMILES

O=C1C(C)=C([[email protected]@H](O)[[email protected]@H](O)/C=C\CC)O[[email protected]]12C(N[[email protected]@](OC)(C(C3=CC=CC=C3)=O)[[email protected]@H]2O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pseurotin AOthersIgEproductionneuritogenicbreastcellscancerBT-474T47DInhibitorinhibitorinhibit

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