1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Detomidine carboxylic acid

Detomidine carboxylic acid 

Cat. No.: HY-135895
Handling Instructions

Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic sedative. Detomidine also has cardiac and respiratory effects and an antidiuretic action.

For research use only. We do not sell to patients.

Detomidine carboxylic acid Chemical Structure

Detomidine carboxylic acid Chemical Structure

CAS No. : 115664-39-6

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Description

Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic sedative. Detomidine also has cardiac and respiratory effects and an antidiuretic action[1][2].

IC50 & Target

α2-adrenergic[2]

In Vivo

Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [3H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [3H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected[1].

Molecular Weight

216.24

Formula

C₁₂H₁₂N₂O₂

CAS No.

115664-39-6

SMILES

O=C(O)C1=CC=CC(CC2=CN=CN2)=C1C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Detomidine carboxylic acidAdrenergic ReceptorBeta ReceptorDetomidineurinarymetaboliteoxidizedformanalgesicsedativeantidiureticα2-adrenergicInhibitorinhibitorinhibit

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Detomidine carboxylic acid
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HY-135895
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