Detomidine carboxylic acid

製品番号: HY-135895: Data Sheet 取扱説明書
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Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action.

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Detomidine carboxylic acid 構造式

CAS 番号 : 115664-39-6

容量	価格（税別）	在庫状況	数量
5 mg	$523	お問い合わせ 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
10 mg	$978	お問い合わせ 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
25 mg	$2330	お問い合わせ 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
50 mg	$3958	お問い合わせ 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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α adrenergic receptor β adrenergic receptor

生物活性
純度とドキュメンテーション
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製品説明	Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action^[1]^[2].
IC₅₀ & Target	α2-adrenergic^[2]
体内実験	Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [³H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [³H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	216.24
分子式	C₁₂H₁₂N₂O₂
CAS 番号	115664-39-6
SMILES	O=C(O)C1=CC=CC(CC2=CN=CN2)=C1C
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	データシート (267 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Salonen JS, et al. Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse. Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):13-20. [Content Brief] [2]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7. [Content Brief]