1. Vitamin D Related
  2. VD/VDR
  3. Calcifediol monohydrate

Calcifediol monohydrate (Synonyms: 25-hydroxy Vitamin D3 monohydrate)

Cat. No.: HY-32351A Purity: 99.89%
Handling Instructions

Calcifediol (monohydrate) is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

For research use only. We do not sell to patients.

Calcifediol monohydrate Chemical Structure

Calcifediol monohydrate Chemical Structure

CAS No. : 63283-36-3

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5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Calcifediol monohydrate:

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Description

Calcifediol (monohydrate) is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

In Vitro

Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1].

Clinical Trial
Molecular Weight

418.65

Formula

C₂₇H₄₆O₃

CAS No.

63283-36-3

SMILES

C=C(CC1)/C(C[[email protected]]1O)=C\C=C2[[email protected]@]3([H])[[email protected]@](CCC\2)(C)[[email protected]@H]([[email protected]](C)CCCC(C)(C)O)CC3.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (238.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3886 mL 11.9432 mL 23.8863 mL
5 mM 0.4777 mL 2.3886 mL 4.7773 mL
10 mM 0.2389 mL 1.1943 mL 2.3886 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

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Keywords:

Calcifediol25-hydroxy Vitamin D3VD/VDRVitamin DVitamin D receptorInhibitorinhibitorinhibit

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Product name:
Calcifediol monohydrate
Cat. No.:
HY-32351A
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