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Tienilic acid  (Synonyms: Ticrynafen; ANP 3624)

Cat. No.: HY-21065 Purity: 99.85%
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Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro.

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Tienilic acid Chemical Structure

Tienilic acid Chemical Structure

CAS No. : 40180-04-9

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Description

Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro[1].

In Vivo

Tienilic acid (100 mg/lg in rats and mice, 5 mg/kg in pigs and dog; PO and IV; single dosage) is only found in plasma, eliminates by the biliary and the urinary fast, and exhibits small differences in the different species[2].
Tienilic acid (0-480 mg/kg; PO; for 28 days) decreases blood pressure, serum, uric acid hemoglobin, and increased S-GPT; induces unicellular necrosis of small groups of liver cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats, mice, pigs and dogs[2]
Dosage: 100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs
Administration: PO and IV; single dosage
Result: Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.
Animal Model: Female and male Sprague-Dawley rats[3]
Dosage: 0, 30, 120 and 480 mg/kg
Administration: PO; for 28 days
Result: Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.
Molecular Weight

331.17

Formula

C13H8Cl2O4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)COC1=CC=C(C(C2=CC=CS2)=O)C(Cl)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (301.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0196 mL 15.0980 mL 30.1960 mL
5 mM 0.6039 mL 3.0196 mL 6.0392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

COA (251 KB) HNMR (274 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0196 mL 15.0980 mL 30.1960 mL 75.4899 mL
5 mM 0.6039 mL 3.0196 mL 6.0392 mL 15.0980 mL
10 mM 0.3020 mL 1.5098 mL 3.0196 mL 7.5490 mL
15 mM 0.2013 mL 1.0065 mL 2.0131 mL 5.0327 mL
20 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7745 mL
25 mM 0.1208 mL 0.6039 mL 1.2078 mL 3.0196 mL
30 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5163 mL
40 mM 0.0755 mL 0.3774 mL 0.7549 mL 1.8872 mL
50 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
60 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2582 mL
80 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9436 mL
100 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7549 mL
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Tienilic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tienilic acid40180-04-9Ticrynafen ANP 3624ANP3624ANP 3624ANP-3624Othersdiuretic hypotensive agentinduces hepatotoxicityInhibitorinhibitorinhibit

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