1. GPCR/G Protein
  2. Prostaglandin Receptor

L 888607 

Cat. No.: HY-111271
Handling Instructions

L 888607 is a potent, and selective CRTH2 (also known as DP2) agonist with a Ki of 0.8±0.4 nM.

For research use only. We do not sell to patients.

L 888607 Chemical Structure

L 888607 Chemical Structure

CAS No. : 860033-06-3

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5 mg USD 450 Get quote
10 mg USD 750 Get quote
25 mg USD 1500 Get quote
50 mg USD 2100 Get quote
100 mg USD 3300 Get quote

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Customer Review

Other Forms of L 888607:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

L 888607 is a potent, and selective CRTH2 (also known as DP2) agonist with a Ki of 0.8±0.4 nM.

IC50 & Target[1]

CRTH2/DP2 Receptor

0.8 nM (Ki)

DP/DP1 Receptor

2331 nM (Ki)

TP Receptor

283 nM (Ki)

EP2 Receptor

8748 nM (Ki)

EP3-III Receptor

1260 nM (Ki)

EP4 Receptor

4634 nM (Ki)

FP Receptor

10018 nM (Ki)

IP Receptor

14434 nM (Ki)

In Vivo

L 888607 (L-888,607) is administered to mice either intravenously (i.v.) or orally (p.o.) to determine its pharmacokinetic profile over an 8-h period. After an intravenous administration of 5 mg/kg L 888607, blood analysis reveals a peak level (Cmax) of 36.1 μM, a half-life (t1/2) of 2.9 h, a trough level at 8 h (C8h) of 3.5 μM, and an area under the curve0-8h of 87.1 μM. After oral administration of 20 mg/kg L 888607, blood analysis reveals a Cmax of 31.6 μM, a t1/2 of 4 h, a C8h at 8 h of 15.4 μM, an area under the curve0-8h of 166 μM, and a bioavailability of 48%[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6607 mL 13.3035 mL 26.6071 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL
10 mM 0.2661 mL 1.3304 mL 2.6607 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Male (ICR)BR mice with an average weight of 42 g are used. A single dose [5 mg/kg in 60% (v/v) polyethylene glycol 200] of L 888607 is given intravenously via the saphenous vein or a single dose (20 mg/kg in 60% (v/v) polyethylene glycol 400) is given orally by gavage. No obvious side effects are observed. Blood (10 μL) is taken from the jugular vein at each time point indicated and added to 30 μL of 0.1 M aqueous trisodium citrate. The mixture is kept at -20°C until analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

375.84

Formula

C₁₉H₁₅ClFNO₂S

CAS No.

860033-06-3

SMILES

O=C(O)C[[email protected]@H]1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
L 888607
Cat. No.:
HY-111271
Quantity:

L 888607

Cat. No.: HY-111271