1. GPCR/G Protein
  2. Prostaglandin Receptor

L 888607 Racemate 

Cat. No.: HY-111271A
Handling Instructions

L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

For research use only. We do not sell to patients.

L 888607 Racemate Chemical Structure

L 888607 Racemate Chemical Structure

CAS No. : 1030017-51-6

Size Price Stock
5 mg USD 450 Get quote
10 mg USD 750 Get quote
25 mg USD 1500 Get quote
50 mg USD 2100 Get quote
100 mg USD 3300 Get quote

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Other Forms of L 888607 Racemate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

IC50 & Target[1]

DP/DP1

132 nM (Ki)

TP

17 nM (Ki)

In Vitro

L 888607 Racemate (compound 3) maintains a modest binding affinity for the DP1 receptor (Ki = 132 nM) and is actually 8-fold more potent on the TP receptor (Ki = 17 nM)[1].

Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (15.96 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6607 mL 13.3035 mL 26.6071 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL
10 mM 0.2661 mL 1.3304 mL 2.6607 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.6 mg/mL (1.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.6 mg/mL (1.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.6 mg/mL (1.60 mM); Clear solution

References
Molecular Weight

375.84

Formula

C₁₉H₁₅ClFNO₂S

CAS No.

1030017-51-6

SMILES

O=C(O)CC1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
L 888607 Racemate
Cat. No.:
HY-111271A
Quantity:

L 888607 Racemate

Cat. No.: HY-111271A